INT232561

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.55
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ELK3) mitochondrion (ELK3) nucleolus (ELK3)
nucleus (ELK3)
Anatomy Link Frequency
faces 1
heart 1
neural 1
ELK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
action potential duration 60 99.76 Very High Very High Very High
amygdala 72 95.84 Very High Very High Very High
lidocaine 27 95.76 Very High Very High Very High
tetrodotoxin 3 74.80 Quite High
Potency 3 70.04 Quite High
Action potential 120 60.40 Quite High
insula 6 51.96 Quite High
Anterior cingulate cortex 2 39.44 Quite Low
sodium channel 3 32.28 Quite Low
Calcium channel 6 23.36 Low Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 6 93.56 High High
Anxiety Disorder 25 84.80 Quite High
Arrhythmias 2 Under Development 9 83.80 Quite High
Heart Rate Under Development 12 79.92 Quite High
Arrhythmia Under Development 27 65.56 Quite High
Cardiovascular Disorder Under Development 12 50.00 Quite Low
Urological Neuroanatomy 3 44.44 Quite Low
Disease 6 20.60 Low Low
Syndrome 24 18.72 Low Low
Sudden Death 3 12.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In all experiments, emotional faces were found to trigger an increased ERP positivity relative to neutral faces.
Positive_regulation (increased) of ERP in faces
1) Confidence 0.46 Published 2007 Journal Neuropsychologia Section Abstract Doc Link PMC2383989 Disease Relevance 0 Pain Relevance 0
The most important evidence against the hypothesis that ERP modulations sensitive to emotional facial expression are generated during the initial automatic classification of emotional content comes from our finding that spatial attention had a strong modulatory effect on these modulations.
Positive_regulation (generated) of ERP
2) Confidence 0.43 Published 2007 Journal Neuropsychologia Section Body Doc Link PMC2383989 Disease Relevance 0.08 Pain Relevance 0.16
Van Schie et al. [17] found that when participants observed an erroneous action of another person a mediofrontal negativity akin the ERN emerged in the observer's ERP thus suggesting that similar neural mechanisms are involved in monitoring one's own actions and the actions of others.
Positive_regulation (emerged) of ERP in neural
3) Confidence 0.29 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2918625 Disease Relevance 0 Pain Relevance 0
Quinidine was found to increase ERP in a rate-independent manner in humans (Rosenheck et al. 1990).
Positive_regulation (increase) of ERP
4) Confidence 0.10 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0.08 Pain Relevance 0.27
Interestingly, the ability of dofetilide to increase ERP was found to be decreased at higher heart rates and increased at low heart rates (Bauer et al. 1999), which could be related to drug-induced increased pro-arrhythmic risk as described above.
Positive_regulation (increase) of ERP in heart
5) Confidence 0.10 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0.30 Pain Relevance 0.14
Class I drugs have been traditionally subdivided into three categories—Ia, Ib and Ic—according to their kinetics of action (intermediate, fast and slow, respectively; Trevor & Katzung 2003) and also their different effects on the effective refractory period (ERP): class Ib drugs markedly depressed ERP (and shortened APD), whereas Ic drugs had minor effects on ERP and the Ia subgroup moderately prolonged ERP (and APD; Campbell 1983).
Positive_regulation (prolonged) of ERP associated with action potential duration
6) Confidence 0.06 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0.08 Pain Relevance 0.30

General Comments

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