INT23257

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Context Info
Confidence 0.62
First Reported 1990
Last Reported 2011
Negated 24
Speculated 16
Reported most in Body
Documents 127
Total Number 143
Disease Relevance 100.05
Pain Relevance 21.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
Anatomy Link Frequency
plasma 9
blood 5
body 5
joints 4
hip 2
CRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1955 100.00 Very High Very High Very High
cytokine 496 100.00 Very High Very High Very High
diclofenac 212 100.00 Very High Very High Very High
Inflammatory marker 161 100.00 Very High Very High Very High
rheumatoid arthritis 658 99.78 Very High Very High Very High
Arthritis 253 99.72 Very High Very High Very High
visual analogue scale 10 99.64 Very High Very High Very High
anesthesia 30 99.08 Very High Very High Very High
addiction 72 98.98 Very High Very High Very High
Etanercept 103 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2270 100.00 Very High Very High Very High
Obesity 706 100.00 Very High Very High Very High
Cardiovascular Disease 692 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 512 100.00 Very High Very High Very High
Stress 339 100.00 Very High Very High Very High
Thyroiditis 164 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 145 100.00 Very High Very High Very High
Ulcers 10 100.00 Very High Very High Very High
Coronary Artery Disease 843 99.98 Very High Very High Very High
Pneumonia 96 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reviewers further conclude that acupuncture has no effect on ESR, CRP, pain, patient's global assessment, number of swollen joints, number of tender joints, general health, disease activity and reduction of analgesics.
Neg (no) Regulation (effect) of CRP in joints
1) Confidence 0.62 Published 2002 Journal Cochrane Database Syst Rev Section Body Doc Link 12137715 Disease Relevance 0 Pain Relevance 0
CONCLUSION: This study shows that the CRP synonymous 1059G/C polymorphism affects CRP levels.
Regulation (affects) of CRP
2) Confidence 0.62 Published 2007 Journal Coron. Artery Dis. Section Body Doc Link 17925606 Disease Relevance 0 Pain Relevance 0
Previous studies have shown that certain medications have an effect on CRP levels in the body [16–22].
Regulation (effect) of CRP in body
3) Confidence 0.61 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872322 Disease Relevance 1.43 Pain Relevance 0.34
Hormone replacement therapy (HRT) and raloxifene on the other hand had no effect on CRP levels in post menopausal women [22].
Neg (no) Regulation (effect) of CRP associated with endometriosis (extended)
4) Confidence 0.61 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872322 Disease Relevance 0.95 Pain Relevance 0.31
In addition to body fatness, CRP can be affected by age, smoking, medications, biochemical indices, dietary factors, lifestyle factors, genetics and race.
Regulation (affected) of CRP in body associated with nicotine addiction
5) Confidence 0.61 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872322 Disease Relevance 1.48 Pain Relevance 0.29
Diclofenac intervention did not affect levels of the known inflammation markers CRP, sialic acid, VCAM or ICAM.
Neg (not) Regulation (affect) of CRP associated with inflammation and diclofenac
6) Confidence 0.59 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2837611 Disease Relevance 0.50 Pain Relevance 0.34
As changes in serum CRP levels reflect the presence and intensity of inflammation, CRP has been used as a clinical marker to assess the inflammatory status in many diseases.
Regulation (changes) of serum CRP associated with inflammation and disease
7) Confidence 0.54 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2989710 Disease Relevance 1.65 Pain Relevance 0.44
In general, body fatness had a greater affect on hs-CRP for subjects without diabetes than subjects with diabetes, which was an unexpected result.
Regulation (affect) of hs-CRP in body associated with diabetes mellitus
8) Confidence 0.53 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872322 Disease Relevance 1.54 Pain Relevance 0.07
CONCLUSION: This study shows that the CRP synonymous 1059G/C polymorphism affects CRP levels.
Regulation (affects) of CRP
9) Confidence 0.45 Published 2007 Journal Coron. Artery Dis. Section Body Doc Link 17925606 Disease Relevance 0 Pain Relevance 0
Whether genetic factors such as the synonymous 1059G/C polymorphism within the exon 2 of the human CRP gene determine CRP levels and outcome is unclear.
Spec (determine) Regulation (determine) of CRP
10) Confidence 0.45 Published 2007 Journal Coron. Artery Dis. Section Abstract Doc Link 17925606 Disease Relevance 0.17 Pain Relevance 0.17
Therefore, CRP levels in HT appear to be independent from thyroid function status.
Neg (independent) Regulation (independent) of CRP in thyroid associated with thyroiditis
11) Confidence 0.45 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2989710 Disease Relevance 1.38 Pain Relevance 0.10
In this study, changes in the ESR and CRP levels were observed to assess the improvement in chronic inflammation.
Regulation (changes) of CRP associated with inflammation
12) Confidence 0.45 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2824092 Disease Relevance 0.70 Pain Relevance 0.40
Changes in the ESR and CRP between Before and After the Etanercept Treatment
Regulation (Changes) of CRP associated with etanercept
13) Confidence 0.45 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2824092 Disease Relevance 0.11 Pain Relevance 0.15
Efstratiadis et al. discovered that after controlling for BMI and various CRP confounders, diabetes was not associated with CRP [30].
Regulation (controlling) of CRP associated with diabetes mellitus and obesity
14) Confidence 0.45 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872322 Disease Relevance 1.75 Pain Relevance 0.04
The calculated CRP index was 175 ± 38 in the early obliterative lesions on day 4, but only 18 ± 4 in the mature, collagen-rich plugs on day 28.
Regulation (calculated) of CRP in plugs
15) Confidence 0.44 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2686807 Disease Relevance 0.31 Pain Relevance 0.09
Ridker and colleagues analysed the predictive capabilities of CRP as related to other known risk factors among participants of the Physicians’ Health Study and provided evidence for an independent predictive role of circulating CRP for coronary events and peripheral arterial disease in initially healthy subjects (

Ridker and others, 1997

Ridker and others, 1998a

).

Regulation (circulating) of CRP associated with peripheral arterial disease
16) Confidence 0.44 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688374 Disease Relevance 0.70 Pain Relevance 0.10
High sensitive CRP has been advocated as the most attractive candidate novel bio-marker for inclusion in existing risk prediction models, primarily due to its stability, low diurnal variation, and ease of measurement [9]. hsCRP has been accepted to provide additional value to the Framingham risk scoring system devised for future 10yr CAD risk prediction, even in the presence of conventional CAD risk factors [10–13].
Regulation (sensitive) of CRP associated with coronary artery disease
17) Confidence 0.44 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC2989863 Disease Relevance 0.89 Pain Relevance 0.16
2 carriers [19,21] or no effect of APOE genotype on plasma CRP at all [22].
Neg (no) Regulation (effect) of CRP in plasma
18) Confidence 0.43 Published 2010 Journal Human Immunology Section Body Doc Link PMC2837141 Disease Relevance 0.31 Pain Relevance 0
However, we have clearly demonstrated that the APOE genotype influences CRP concentrations.
Regulation (influences) of CRP
19) Confidence 0.43 Published 2010 Journal Human Immunology Section Body Doc Link PMC2837141 Disease Relevance 0.85 Pain Relevance 0.08
The contrast between the fibrinogen-lowering effect of bezafibrate and the absence of any effect on CRP is clear.
Regulation (effect) of CRP
20) Confidence 0.41 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC57751 Disease Relevance 1.22 Pain Relevance 0.22

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