INT232598

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.05
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR1H2) nucleus (NR1H2) DNA binding (NR1H2)
cytoplasm (NR1H2)
NR1H2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 18 97.52 Very High Very High Very High
Potency 12 95.48 Very High Very High Very High
aspirin 2 38.08 Quite Low
Paracetamol 10 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 52 99.80 Very High Very High Very High
Nicotine Addiction 41 98.44 Very High Very High Very High
Toxicity 7 71.24 Quite High
Disease 120 70.56 Quite High
Pancreatic Cancer 4 36.44 Quite Low
Apoptosis 8 35.44 Quite Low
Head & Neck Cancer 1 28.12 Quite Low
Cancer 42 22.64 Low Low
Bladder Cancer 16 5.00 Very Low Very Low Very Low
Breast Cancer 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found no statistically significant associations between the PXR and LXR polymorphisms and CRC risk, and no interaction with smoking status, use of NSAID, or intake of red and processed meat.
Gene_expression (polymorphisms) of LXR associated with nicotine addiction, colon cancer and cinod
1) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949803 Disease Relevance 0.79 Pain Relevance 0.10
The one-step CRF performs NER and SRE in one combined operation.
Gene_expression (performs) of NER
2) Confidence 0.29 Published 2008 Journal BMC Bioinformatics Section Body Doc Link PMC2386138 Disease Relevance 0.12 Pain Relevance 0
In two cell lines both expressing CYP1A2 and NAT2, but one deficient in NER, 2,6-DMA and 3,5-DMA were cytotoxic and mutagenic at dose levels between 100 ?
Gene_expression (3,5) of NER
3) Confidence 0.20 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0.07 Pain Relevance 0.09
In two cell lines both deficient in NER and one expressing CYP1A2 and NAT2, 2,6-DMA and 3,5-DMA were cytotoxic at dose levels of 100 ?
Gene_expression (one) of NER
4) Confidence 0.20 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0.06 Pain Relevance 0.08
The levels of NER in the samples were estimated by the ratio of ssDNA to dsDNA at a given UV- or MMC-dose.
Gene_expression (levels) of NER
5) Confidence 0.04 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2770670 Disease Relevance 0 Pain Relevance 0

General Comments

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