INT232604

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Context Info
Confidence 0.72
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.33
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grid2ip)
Anatomy Link Frequency
synapses 3
Grid2ip (Mus musculus)
Pain Link Frequency Relevance Heat
Thalamus 6 99.24 Very High Very High Very High
depression 171 98.76 Very High Very High Very High
addiction 6 95.48 Very High Very High Very High
Glutamate receptor 120 93.52 High High
nMDA receptor 6 78.04 Quite High
long-term potentiation 15 69.36 Quite High
Hippocampus 3 35.60 Quite Low
Action potential 12 5.00 Very Low Very Low Very Low
tetrodotoxin 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 171 98.76 Very High Very High Very High
Congenital Anomalies 12 75.12 Quite High
Sprains And Strains 6 40.00 Quite Low
Intellectual Impairment 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, Delphilin mutant mice should be useful for this plasticity enhancement approach because Delphilin is selectively localized at PF-PC synapses and its ablation facilitates LTD induction with little effect on the maximal amplitude of LTD expression.
Localization (localized) of Delphilin in synapses associated with depression
1) Confidence 0.72 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.43 Pain Relevance 0.38
Within PCs, Delphilin is localized at PF synapses, but not at CF synapses.
Neg (not) Localization (localized) of Delphilin in synapses
2) Confidence 0.72 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.31 Pain Relevance 0.54
Delphilin is distributed predominantly in cerebellar PCs and is localized selectively at PF synapses within PCs [22].
Localization (localized) of Delphilin in synapses
3) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.59 Pain Relevance 0.52

General Comments

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