INT232628

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Context Info
Confidence 0.78
First Reported 2008
Last Reported 2009
Negated 7
Speculated 0
Reported most in Body
Documents 10
Total Number 34
Disease Relevance 17.01
Pain Relevance 0.26

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mitochondrion (Opa1) mitochondrion organization (Opa1) GTPase activity (Opa1)
Anatomy Link Frequency
cervix 2
fibroblasts 1
Opa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 63 95.92 Very High Very High Very High
imagery 4 64.64 Quite High
pain pelvic 25 34.40 Quite Low
Inflammation 48 29.68 Quite Low
depression 45 5.00 Very Low Very Low Very Low
pruritus 45 5.00 Very Low Very Low Very Low
headache 19 5.00 Very Low Very Low Very Low
Dysuria 10 5.00 Very Low Very Low Very Low
cva 8 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 975 99.84 Very High Very High Very High
Infection 460 99.68 Very High Very High Very High
Gonorrhea 325 99.36 Very High Very High Very High
Neuroleptic Malignant Syndrome 225 97.28 Very High Very High Very High
Systemic Mastocytosis 195 96.72 Very High Very High Very High
Pain 43 95.92 Very High Very High Very High
Optic Disorders 32 94.48 High High
Mastocytosis 445 93.44 High High
Chlamydia Infection 125 92.52 High High
Apoptosis 16 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of OPA1 protein
Gene_expression (Expression) of OPA1
1) Confidence 0.78 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2661005 Disease Relevance 0 Pain Relevance 0.03
Expression of OPA1 protein
Gene_expression (Expression) of OPA1
2) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2661005 Disease Relevance 0 Pain Relevance 0.03
We also observed no alteration of the OPA1 expression pattern in these cells (Figure 7).


Gene_expression (expression) of OPA1
3) Confidence 0.60 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2661005 Disease Relevance 0.54 Pain Relevance 0
In spite of the mutation, there was no quantitative modification of OPA1 expression in the patient’s fibroblasts.
Gene_expression (expression) of OPA1 in fibroblasts
4) Confidence 0.60 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2661005 Disease Relevance 0.51 Pain Relevance 0
The antigenically variable neisserial opacity (Opa) proteins are expressed during infection and have a semivariable (SV) and highly conserved (4L) loop that could be targeted in a vaccine.
Gene_expression (expressed) of Opa associated with infection
5) Confidence 0.56 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2779592 Disease Relevance 0.27 Pain Relevance 0
The expression of Opa proteins by N. gonorrhoeae appears to be important during urogenital tract infections.
Gene_expression (expression) of Opa associated with infection
6) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779592 Disease Relevance 0.55 Pain Relevance 0
Each opa gene undergoes phase variation via a frame shift mechanism, and therefore, a single gonococcus can express no Opa proteins, one Opa protein, or multiple Opa proteins simultaneously [17], [18].
Neg (no) Gene_expression (express) of Opa
7) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779592 Disease Relevance 0.39 Pain Relevance 0
Each opa gene undergoes phase variation via a frame shift mechanism, and therefore, a single gonococcus can express no Opa proteins, one Opa protein, or multiple Opa proteins simultaneously [17], [18].
Neg (no) Gene_expression (express) of Opa
8) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779592 Disease Relevance 0.44 Pain Relevance 0
The majority of urethral isolates from naturally [19] and experimentally infected men [20], [21] expressed one or more Opa proteins, and in women, mostly Opa-positive isolates were recovered from the cervix during certain stages of the menstrual cycle [19].
Gene_expression (expressed) of Opa in cervix
9) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779592 Disease Relevance 0.51 Pain Relevance 0
Antibodies to the 4L peptide did not bind Opa-expressing bacteria.
Gene_expression (expressing) of Opa
10) Confidence 0.56 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2779592 Disease Relevance 0.30 Pain Relevance 0
Where indicated, recombinant strains of FA1090 that express no Opa proteins or that constitutively express only OpaB were used (kindly provided by Janne Cannon, University of North Carolina).
Neg (no) Gene_expression (express) of Opa associated with sprains and strains
11) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779592 Disease Relevance 0.69 Pain Relevance 0
Here we analyzed antibodies against peptides that correspond to the SV and 4L loops for the capacity to bind to gonococci that express different Opa proteins and for correlates of antibody-mediated protection.
Gene_expression (express) of Opa
12) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779592 Disease Relevance 0.34 Pain Relevance 0
Strain FA1090 expresses 8 antigenically distinct Opa proteins: OpaA, OpaB, OpaC, OpaD, OpaE, OpaF, OpaI and OpaK.
Gene_expression (expresses) of Opa associated with sprains and strains
13) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779592 Disease Relevance 0.90 Pain Relevance 0
Each opa gene undergoes phase variation via a frame shift mechanism, and therefore, a single gonococcus can express no Opa proteins, one Opa protein, or multiple Opa proteins simultaneously [17], [18].
Neg (no) Gene_expression (express) of Opa
14) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779592 Disease Relevance 0.39 Pain Relevance 0
Evidence for Opa protein expression during infection is also supported by the detection of Opa protein-specific antibodies in serum and genital secretions from men and women with uncomplicated urogenital tract infections, PID, or disseminated gonococcal infection [22], [23].
Gene_expression (expression) of Opa associated with gonorrhea, chlamydia infection and infection
15) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779592 Disease Relevance 0.64 Pain Relevance 0
Stock Opa variants expressed LOS species with the same banding pattern on silver stained tricine gels (data not shown) and stocks composed of either mostly piliated or nonpiliated variants were maintained.
Gene_expression (expressed) of Opa
16) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779592 Disease Relevance 0.90 Pain Relevance 0
AbSV cyclic agglutinated OpaA and OpaB variants but not OpaK variants at a titer of 1?
Gene_expression (variants) of OpaK
17) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779592 Disease Relevance 0.78 Pain Relevance 0
For example, Opa-expressing gonococci are preferentially recovered from experimentally infected male volunteers [20], [21] and during lower genital tract infection of female mice [30].
Gene_expression (expressing) of Opa associated with infection
18) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779592 Disease Relevance 0.22 Pain Relevance 0
These antibodies could potentially recognize many Opa variants produced by different gonococcal strains and therefore, the use of different adjuvants or other strategies to induce high titered SV loop-specific antibodies with bactericidal activity that can be delivered systemically is warranted.
Gene_expression (produced) of Opa associated with sprains and strains
19) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779592 Disease Relevance 0.54 Pain Relevance 0
Consistent with the results obtained by SBI, AbSV linear (2.2 µg/mL) bound OpaA variants as well as OpaK and OpaF-expressing gonococci, but none of the other Opa variants.
Neg (none) Gene_expression (expressing) of OpaK
20) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779592 Disease Relevance 0 Pain Relevance 0

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