INT232631

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 2.25
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cd2) cell adhesion (Cd2) protein complex (Cd2)
Anatomy Link Frequency
bone marrow 2
Cd2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 62.72 Quite High
chemokine 1 62.12 Quite High
Pain 11 52.76 Quite High
depression 9 49.36 Quite Low
abdominal pain 1 46.88 Quite Low
pruritus 9 44.28 Quite Low
Inflammation 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Dysuria 2 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Mastocytosis 39 99.90 Very High Very High Very High
Cutaneous Mastocytosis 24 93.76 High High
Exanthema 1 88.08 High High
Urticaria Pigmentosa 1 87.44 High High
Mast Cell Leukemia 4 86.44 High High
Disease 16 84.28 Quite High
Mastocytosis 89 77.00 Quite High
Pain 7 52.76 Quite High
Osteoporosis 1 52.36 Quite High
Heart Rate Under Development 2 50.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Minor criteria for a diagnosis of SM can include abnormal mast cell morphologies in the bone marrow and other extracutaneous organs, mutation of the tyrosine kinase KIT at codon 816, expression of CD2 and/or CD25 by bone marrow mast cells, and a serum tryptase level >20 ng/mL.
Negative_regulation (include) of Gene_expression (expression) of CD2 in bone marrow associated with systemic mastocytosis
1) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 2.25 Pain Relevance 0.12

General Comments

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