INT232633

Context Info Confidence 0.27 First Reported 2008 Last Reported 2009 Negated 3 Speculated 1 Reported most in Body Documents 2 Total Number 4 Disease Relevance 2.60 Pain Relevance 0

mitochondrion (Opa1) mitochondrion organization (Opa1) GTPase activity (Opa1)

Anatomy Link Frequency fibroblasts 2 Opa1 (Mus musculus)

Pain Link Frequency Relevance Heat Pain 26 5.00 depression 18 5.00 pruritus 18 5.00 Inflammation 10 5.00 headache 8 5.00 cva 4 5.00 Dysuria 4 5.00 cytokine 2 5.00 alcohol 2 5.00 abdominal pain 2 5.00

Disease Link Frequency Relevance Heat Systemic Mastocytosis 78 97.64 Optic Disorders 16 94.48 Apoptosis 8 91.44 Mastocytosis 178 90.88 Pallor 4 77.20 Scotoma 8 74.40 Disease 54 71.24 Cutaneous Mastocytosis 48 69.04 Ganglion Cysts 6 62.32 Optic Atrophy 12 59.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In spite of the mutation, there was no quantitative modification of OPA1 expression in the patient’s fibroblasts.

Neg (no) Regulation (modification) of Gene_expression (expression) of OPA1 in fibroblasts

1) Confidence 0.27 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2661005 Disease Relevance 0.51 Pain Relevance 0

We also observed no alteration of the OPA1 expression pattern in these cells (Figure 7).

Neg (no) Regulation (alteration) of Gene_expression (expression) of OPA1

2) Confidence 0.27 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2661005 Disease Relevance 0.54 Pain Relevance 0

As shown in Table 1, there was no significant difference between the OPA score according to the presence of an elevated (?

Neg (no) Regulation (difference) of Gene_expression (score) of OPA

3) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 0.70 Pain Relevance 0

We also examined the correlation between the OPA score and the total serum tryptase level because a level ?

Spec (examined) Regulation (correlation) of Gene_expression (score) of OPA

4) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 0.85 Pain Relevance 0

General Comments

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