INT232639

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 10.63
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Jag2)
Anatomy Link Frequency
mast cell 3
fibroblasts 1
Jag2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 25 91.60 High High
agonist 24 85.92 High High
cytokine 15 81.80 Quite High
chemokine 3 81.20 Quite High
Pain 33 71.84 Quite High
depression 27 68.44 Quite High
abdominal pain 3 65.96 Quite High
pruritus 27 63.36 Quite High
headache 9 5.00 Very Low Very Low Very Low
Dysuria 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Mastocytosis 117 100.00 Very High Very High Very High
Mast Cell Leukemia 12 99.76 Very High Very High Very High
Stress 76 99.68 Very High Very High Very High
Disease 48 99.66 Very High Very High Very High
Cutaneous Mastocytosis 72 98.68 Very High Very High Very High
Mastocytosis 267 98.04 Very High Very High Very High
Apoptosis 252 97.52 Very High Very High Very High
INFLAMMATION 29 91.60 High High
Chondrodysplasia 4 79.68 Quite High
Targeted Disruption 11 76.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This system separates mastocytosis into cutaneous mastocytosis (CM) and five main subtypes of systemic mastocytosis (SM), including indolent SM, SM with an associated hematologic clonal, non-mast cell lineage disease, aggressive SM, smoldering SM, and mast cell leukemia.
Positive_regulation (indolent) of SM in mast cell associated with cutaneous mastocytosis, systemic mastocytosis, mast cell leukemia, disease and mastocytosis
1) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 2.82 Pain Relevance 0.29
This system separates mastocytosis into cutaneous mastocytosis (CM) and five main subtypes of systemic mastocytosis (SM), including indolent SM, SM with an associated hematologic clonal, non-mast cell lineage disease, aggressive SM, smoldering SM, and mast cell leukemia.
Positive_regulation (indolent) of SM in mast cell associated with cutaneous mastocytosis, systemic mastocytosis, mast cell leukemia, disease and mastocytosis
2) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 2.82 Pain Relevance 0.29
This system separates mastocytosis into cutaneous mastocytosis (CM) and five main subtypes of systemic mastocytosis (SM), including indolent SM, SM with an associated hematologic clonal, non-mast cell lineage disease, aggressive SM, smoldering SM, and mast cell leukemia.
Positive_regulation (smoldering) of SM in mast cell associated with cutaneous mastocytosis, systemic mastocytosis, mast cell leukemia, disease and mastocytosis
3) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 2.76 Pain Relevance 0.27
Altogether, these data strongly suggest that nSMase2, which is mutated and deficient in fro/fro mice [19], is activated and required for the activation of the SM/Cer pathway elicited by TNF?
Positive_regulation (activation) of SM/Cer
4) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.24 Pain Relevance 0.04
In order to define the specific contributions of nSMase2 to these stress responses, the activation of the SM/Cer pathway by TNF?
Positive_regulation (activation) of SM/Cer associated with stress
5) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.49 Pain Relevance 0.06
and oxLDLs trigger nSMase activation, SM hydrolysis, and ceramide generation, potentially involved in apoptotic signaling.
Positive_regulation (activation) of SM associated with apoptosis
6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 1.10 Pain Relevance 0.05
and oxLDLs triggered both SM hydrolysis (Figure 2A,B) and nSMase activation in wt fibroblasts (Figure 2D).
Positive_regulation (activation) of SM in fibroblasts
7) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843740 Disease Relevance 0.40 Pain Relevance 0.04

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