INT232652

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.28
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD2, ITGAL) signal transduction (ITGAL) extracellular region (CD2)
cell adhesion (ITGAL)
Anatomy Link Frequency
leukocyte 1
CD2 (Homo sapiens)
ITGAL (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 43 95.24 Very High Very High Very High
Inflammation 6 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Etanercept 2 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 44 95.24 Very High Very High Very High
Apoptosis 3 92.24 High High
Infection 14 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Hepatitis C Virus Infection 3 5.00 Very Low Very Low Very Low
Hypersensitivity 3 5.00 Very Low Very Low Very Low
Common Cold 3 5.00 Very Low Very Low Very Low
Seronegative Spondarthritis 3 5.00 Very Low Very Low Very Low
Erythema 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With its dual mechanism of action, alefacept blocks the interaction between the leukocyte-function-associated antigen (LFA)-3 and CD2 and thereby impedes the activation and proliferation of T cells.
CD2 Binding (interaction) of LFA in leukocyte
1) Confidence 0.03 Published 2007 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2386357 Disease Relevance 0.28 Pain Relevance 0.09

General Comments

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