INT232661

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.81
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

GPM6A (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 44 98.64 Very High Very High Very High
Morphine 44 98.62 Very High Very High Very High
Bioavailability 1 98.38 Very High Very High Very High
Central nervous system 7 89.68 High High
Opioid 74 83.92 Quite High
opioid receptor 4 75.36 Quite High
tolerance 7 64.96 Quite High
Pain management 20 50.00 Quite Low
carbamazepine 4 49.52 Quite Low
Pain 137 46.56 Quite Low
Disease Link Frequency Relevance Heat
Cirrhosis 1 97.96 Very High Very High Very High
Renal Insufficiency 4 94.92 High High
Toxicity 4 92.52 High High
Cancer 61 88.24 High High
Myoclonus 2 84.96 Quite High
Frailty 2 72.96 Quite High
Constipation 6 62.40 Quite High
Vomiting 11 57.48 Quite High
Cognitive Disorder 3 51.48 Quite High
Epilepsy 1 50.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cirrhosis, the bioavailability of morphine is increased due to the lack of first pass metabolism; however, the production of the more potent M6G metabolite may decrease resulting in a less than optimal analgesic effect.
Spec (may) Negative_regulation (decrease) of Gene_expression (production) of M6G associated with cirrhosis, analgesic, morphine and bioavailability
1) Confidence 0.02 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386360 Disease Relevance 0.81 Pain Relevance 1.20

General Comments

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