INT232663

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Context Info
Confidence 0.13
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.08
Pain Relevance 5.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (CCT6A) protein folding (CCT6A) cytosol (CCT6A)
cytoplasm (CCT6A)
Anatomy Link Frequency
superior 1
CCT6A (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 176 100.00 Very High Very High Very High
Bioavailability 4 99.92 Very High Very High Very High
Pain 548 98.40 Very High Very High Very High
Breakthrough pain 16 96.92 Very High Very High Very High
Opioid 296 96.76 Very High Very High Very High
Analgesic 176 94.12 High High
Central nervous system 28 92.76 High High
Cancer pain 176 90.12 High High
tolerance 28 88.60 High High
analgesia 40 85.12 High High
Disease Link Frequency Relevance Heat
Cirrhosis 4 99.50 Very High Very High Very High
Pain 632 98.40 Very High Very High Very High
Renal Insufficiency 16 98.00 Very High Very High Very High
Toxicity 16 95.60 Very High Very High Very High
Cancer Pain 212 90.12 High High
Myoclonus 8 88.04 High High
Constipation 24 86.04 High High
Cancer 244 82.08 Quite High
Vomiting 44 81.12 Quite High
Cognitive Disorder 12 75.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cirrhosis, the bioavailability of morphine is increased due to the lack of first pass metabolism; however, the production of the more potent M6G metabolite may decrease resulting in a less than optimal analgesic effect.
Positive_regulation (increased) of morphine associated with cirrhosis, analgesic, morphine and bioavailability
1) Confidence 0.13 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386360 Disease Relevance 0.82 Pain Relevance 1.21
One study compared its use with oral immediate-release morphine and found OTFC to be superior for fast pain control (Coluzzi et al 2001).
Positive_regulation (immediate-release) of morphine in superior associated with pain and morphine
2) Confidence 0.10 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386360 Disease Relevance 0.80 Pain Relevance 1.40
Thus, a patient requiring morphine 120 mg SR every 12 hours should receive morphine 30 mg IR every 3 hours for breakthrough pain.
Positive_regulation (requiring) of morphine associated with pain, breakthrough pain and morphine
3) Confidence 0.10 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386360 Disease Relevance 0.53 Pain Relevance 1.11
For example, morphine is hepatically glucuronidated to two metabolites: morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G).
Positive_regulation (glucuronidated) of morphine associated with morphine
4) Confidence 0.10 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386360 Disease Relevance 0.94 Pain Relevance 1.56

General Comments

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