INT232666

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.52
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (AK1) small molecule metabolic process (AK1) cytoplasm (AK1)
AK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 26 98.96 Very High Very High Very High
Pain management 40 98.92 Very High Very High Very High
Pain 274 97.88 Very High Very High Very High
COX-2 inhibitor 16 90.96 High High
aspirin 12 87.80 High High
acular 4 84.72 Quite High
Inflammation 12 78.24 Quite High
Analgesic 88 76.76 Quite High
cytokine 2 73.36 Quite High
peptic ulcer disease 2 66.56 Quite High
Disease Link Frequency Relevance Heat
Hemorrhage 8 99.46 Very High Very High Very High
Cancer Pain 106 98.48 Very High Very High Very High
Vomiting 22 93.44 High High
Pain 316 86.36 High High
Cancer 122 79.96 Quite High
Renal Insufficiency 8 79.44 Quite High
INFLAMMATION 14 78.24 Quite High
Disease Progression 4 75.68 Quite High
Acid Base Imbalance 2 74.60 Quite High
Renal Failure 4 73.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With chronic use, they can cause serious gastric ulcerations and bleeding, which is a result of the inhibition of COX-1 isoenzyme.
Negative_regulation (inhibition) of isoenzyme associated with hemorrhage
1) Confidence 0.02 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386360 Disease Relevance 1.61 Pain Relevance 0.88
These drugs specifically inhibit the COX-2 isoenzyme, which is considered the inducible isoenzyme during painful stimuli.
Negative_regulation (inhibit) of isoenzyme associated with pain
2) Confidence 0.02 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386360 Disease Relevance 0.91 Pain Relevance 1.00

General Comments

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