INT232667

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Context Info
Confidence 0.16
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 20.76
Pain Relevance 3.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
autonomic 1
olfactory 1
cholinergic neurons 1
limb 1
head 1
Pd (Mus musculus)
Pain Link Frequency Relevance Heat
depression 105 99.98 Very High Very High Very High
Locus ceruleus 354 99.78 Very High Very High Very High
deep brain stimulation 155 99.48 Very High Very High Very High
sSRI 168 98.38 Very High Very High Very High
Thalamotomy 40 98.36 Very High Very High Very High
Neurobehavioral 5 98.32 Very High Very High Very High
Substantia nigra 23 98.00 Very High Very High Very High
Dopamine 150 96.60 Very High Very High Very High
Serotonin 40 95.40 Very High Very High Very High
cva 5 95.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 1236 100.00 Very High Very High Very High
Panic Disorder 240 100.00 Very High Very High Very High
Heart Arrhythmia 34 100.00 Very High Very High Very High
Respiratory Disease 2 100.00 Very High Very High Very High
Depression 120 99.98 Very High Very High Very High
Tremor 88 99.98 Very High Very High Very High
Dementia 33 99.98 Very High Very High Very High
Dysarthria 15 99.98 Very High Very High Very High
Cognitive Disorder 91 99.80 Very High Very High Very High
Mental Disorders 5 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Assuming a reciprocal neuropsychophysiological interaction between PSVT and PD via either chronic mental and somatic stress or interoceptive processes, immediate and focused differential treatment such as radiofrequency ablation in PSVT or cognitive behavioural psychotherapy, if necessary in combination with pharmacological treatment (for example, with serotonin reuptake inhibitors (SSRI) or noradrenaline and selective serotonin agonists (NaSSA)) in PD is warranted in order to possibly avoid the precipitation of the respective other disorder.


PD Binding (interaction) of associated with stress, panic disorder, cognitive disorder, heart arrhythmia, agonist, noradrenaline, ssri and serotonin
1) Confidence 0.16 Published 2010 Journal Ann Gen Psychiatry Section Body Doc Link PMC2864277 Disease Relevance 1.46 Pain Relevance 0.22
Control animals of all ages had average ODIs of around 0.2 (PD25: 0.18±0.019; PD95: 0.23±0.024; PD130: 0.26±0.013, all n?
PD25 Binding (around) of
2) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518841 Disease Relevance 0 Pain Relevance 0.03
Control animals of all ages had average ODIs of around 0.2 (PD25: 0.18±0.019; PD95: 0.23±0.024; PD130: 0.26±0.013, all n?
PD130 Binding (around) of
3) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518841 Disease Relevance 0 Pain Relevance 0.03
Yet, a growing body of research demonstrates that PD is also associated with an array of sensory or perceptual deficits, such as impairments in olfactory function, tactile discrimination and weight perception [1]–[5].
PD Binding (associated) of in olfactory associated with disease and loss of sense of smell
4) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440419 Disease Relevance 0.87 Pain Relevance 0
However, there is a paucity of psychophysical studies which systematically examined the ability of PD patients to integrate somatosensory cues about limb motion and forces which form the basis of haptic perception.
PD Spec (examined) Binding (integrate) of in limb associated with disease
5) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440419 Disease Relevance 0.88 Pain Relevance 0
Our data demonstrate that PD is associated with a decreased acuity of the haptic sense, which may occur already at an early stage of the disease.



PD Binding (associated) of associated with disease
6) Confidence 0.02 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2440419 Disease Relevance 0.36 Pain Relevance 0
The results from this experiment add to the growing body of literature indicating that PD is associated with a loss of proprioceptive function.
PD Binding (associated) of in body associated with disease
7) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440419 Disease Relevance 0.71 Pain Relevance 0
Recent studies have shown that PD is also associated with extensive non-dopaminergic pathology involving noradrenergic neurons in the locus coeruleus, cholinergic neurons in the nucleus basalis of Meynert, serotonergic neurons in the midline raphe, and neurons of the autonomic nervous system.2 The seminal work of Braak et al has demonstrated that the pathological changes in PD occur in a relatively predictable, topographically distinct sequence of events beginning with the olfactory structures and medulla oblongata, spreading to the substantia nigra, and eventually affecting neocortical structures.3
PD Binding (associated) of in cholinergic neurons associated with medulla, substantia nigra, locus ceruleus, disease and raphe
8) Confidence 0.02 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2877525 Disease Relevance 1.40 Pain Relevance 0.31
In addition to motor symptoms, PD is associated with a host of non-motor symptoms including autonomic disturbance, sleep disorders, depression, psychosis, and dementia.
PD Binding (associated) of in autonomic associated with dementia, depression, psychosis, sleep disorders and disease
9) Confidence 0.02 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2877525 Disease Relevance 1.31 Pain Relevance 0.12
In addition to a loss of LC neurones, PD is also associated with morphological changes to the surviving neurones in the LC, including changes in the size and shape of both pre- and postsynaptic components of synapses, polymorphisms of the synaptic vesicles, changes in the morphology of the mitochondria, swelling of the cell bodies, inclusion of Lewy bodies, and shortening and thinning of the dendrites with absent or reduced arborisations [23, 64, 332].
PD Binding (associated) of in synapses associated with parkinson's disease, pressure and volume under development and locus ceruleus
10) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687931 Disease Relevance 0.61 Pain Relevance 0.60
PD is frequently associated with other mental disorders during life-time: mood disorders, in particular major depression (Kessler et al 1998; Simon and Fischmann 2005), anxiety disorders, in particular agoraphobia (Goisman et al 1994), and alcohol abuse (Zimmermann et al 2003) are observed in many PD patients.
PD Binding (associated) of associated with mental disorders, panic disorder, depression, affective disorder, anxiety disorder, agoraphobia and alcohol
11) Confidence 0.01 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515914 Disease Relevance 1.43 Pain Relevance 0.09
Since PD mimics many life-threatening conditions (ie, cardiac or respiratory diseases) or is often associated with a catastrophic misinterpretation of physical sensations, PD induces a high use of medical services, particularly emergency departments (Katerndahl and Realini 1995; Ballenger 1997; Marchesi et al 2001; Marchesi et al 2004).
PD Binding (associated) of in respiratory associated with panic disorder, emergencies and respiratory disease
12) Confidence 0.01 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515914 Disease Relevance 1.25 Pain Relevance 0.04
Recent studies have shown that PD is also associated with extensive non-dopaminergic pathology involving noradrenergic neurons in the locus coeruleus, cholinergic neurons in the nucleus basalis of Meynert, serotonergic neurons in the midline raphe, and neurons of the autonomic nervous system.2 The seminal work of Braak et al has demonstrated that the pathological changes in PD occur in a relatively predictable, topographically distinct sequence of events beginning with the olfactory structures and medulla oblongata, spreading to the substantia nigra, and eventually affecting neocortical structures.3
PD Binding (associated) of in locus coeruleus associated with medulla, substantia nigra, locus ceruleus, disease and raphe
13) Confidence 0.01 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2877525 Disease Relevance 1.40 Pain Relevance 0.31
Association with Parkinson’s disease (PD) remains controversial but possible (Appiah-Kubi et al 2002; Ondo et al 2002; Garcia-Borreguero et al 2003; Maniak et al 2004; Rye 2004).
PD Binding (Association) of associated with disease
14) Confidence 0.01 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671772 Disease Relevance 1.78 Pain Relevance 0
The largest and best-designed study of rivastigmine in dementia associated with PD involved 541 patients enrolled in a 24-week randomized, multicenter, double-blind clinical trial (Emre et al 2004).
PD Binding (associated) of associated with dementia and disease
15) Confidence 0.00 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536542 Disease Relevance 1.19 Pain Relevance 0.07
There are some conflicting data whether the selective serotonin receptor inhibitors (SSRIs) exacerbate Parkinsonism, but a study of 30 PD patients, (Ceravolo et al 2000) found paroxetine, one of the typical SSRIs, at doses of 20 mg/day, to be safe and effective in the treatment of depression associated with PD.
PD Binding (associated) of associated with parkinson's disease, depression, disease, ssri and serotonin
16) Confidence 0.00 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536542 Disease Relevance 1.63 Pain Relevance 0.66
In addition to improving distal tremor associated with PD and ET, VIM DBS can effectively control ET head tremor, which usually does not respond to conventional therapy.
PD Binding (associated) of in head associated with tremor, deep brain stimulation and disease
17) Confidence 0.00 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536542 Disease Relevance 1.32 Pain Relevance 0.82
Treatment of cognitive deficits associated with PD is as challenging as the treatment of Alzheimer’s disease and other dementias.
PD Binding (associated) of associated with cognitive disorder, dementia and disease
18) Confidence 0.00 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536542 Disease Relevance 1.01 Pain Relevance 0.08
Speech therapy designed to stimulate increased vocal fold adduction with instructions to “increase loudness”, the so called Lee Silverman Voice Treatment (LSVT), using various verbal cues to regulate speech volume, and percutaneous collagen augmentation of the vocal folds (Hill et al 2003) have been used successfully to treat the hypophonic, hypokinetic dysarthria associated with PD.
PD Binding (associated) of associated with disease and dysarthria
19) Confidence 0.00 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536542 Disease Relevance 0.69 Pain Relevance 0.03
However, none of these agents retards the progressive neurodegeneration associated with PD.
PD Binding (associated) of associated with disease
20) Confidence 0.00 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2386362 Disease Relevance 1.44 Pain Relevance 0.16

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