INT232713

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.43
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PDGFRA) nucleus (PDGFRA) extracellular matrix organization (PDGFRA)
cytoplasm (PDGFRA)
PDGFRA (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 1 56.32 Quite High
cva 1 51.12 Quite High
Pain 2 12.16 Low Low
tolerance 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gastrointestinal Stromal Tumor 24 99.56 Very High Very High Very High
Cancer 11 96.48 Very High Very High Very High
Disease Progression 6 95.08 Very High Very High Very High
Metastasis 8 77.48 Quite High
Recurrence 4 75.60 Quite High
Vomiting 2 62.08 Quite High
Diarrhoea 3 61.44 Quite High
Pressure And Volume Under Development 1 60.56 Quite High
Cramps 1 58.96 Quite High
Fatigue 1 57.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Imatinib binds to the intracellular activation pockets of the KIT and PDGFRA receptors in their inactive position, blocking their binding to ATP and preventing growth signals being sent, which stops disease progression.
PDGFRA Binding (binds) of associated with disease progression
1) Confidence 0.35 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2386476 Disease Relevance 1.43 Pain Relevance 0.08

General Comments

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