INT232784

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.05
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsa) mitochondrion (Ctsa) nucleus (Ctsa)
lysosome (Ctsa)
Anatomy Link Frequency
peritoneal macrophages 1
Ctsa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 42 99.62 Very High Very High Very High
imagery 30 94.32 High High
Inflammatory response 8 83.88 Quite High
spinal inflammation 1 76.08 Quite High
Inflammatory mediators 2 65.76 Quite High
cytokine 6 63.84 Quite High
antagonist 1 62.24 Quite High
cva 2 48.52 Quite Low
Tetrahydrobiopterin 4 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 51 99.62 Very High Very High Very High
Cancer 65 99.52 Very High Very High Very High
Urological Neuroanatomy 1 98.92 Very High Very High Very High
Sarcoma 26 92.72 High High
Sepsis 45 88.36 High High
Infection 5 84.40 Quite High
Systemic Inflammatory Response Syndrome 7 83.92 Quite High
Bacterial Infection 3 82.08 Quite High
Disease 1 78.72 Quite High
Low Back Pain 1 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We were able to demonstrate that anti-inflammatory regiments such as ablation of cathepsin B or treatment of mice with anti-TNF?
Localization (ablation) of cathepsin associated with inflammation
1) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 0.81 Pain Relevance 0.31
Tumor-associated macrophages release cathepsin, whereas LPS activated peritoneal macrophages release caspases, both are proteolytic enzymes [31,32].
Localization (release) of cathepsin in peritoneal macrophages associated with cancer
2) Confidence 0.12 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956094 Disease Relevance 0.81 Pain Relevance 0.19
In addition, PMN release granular enzymes (e.g. elastase, cathepsin) and the myeloperoxidase (MPO)-derived oxidant, hypochlorous acid (HOCl).
Localization (release) of cathepsin associated with urological neuroanatomy
3) Confidence 0.02 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386519 Disease Relevance 1.44 Pain Relevance 0.24

General Comments

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