INT232785

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 12
Disease Relevance 10.37
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Anatomy Link Frequency
nucleus 1
heart 1
Hif1a (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 20 98.64 Very High Very High Very High
imagery 304 98.44 Very High Very High Very High
Inflammation 97 97.32 Very High Very High Very High
ketamine 8 83.44 Quite High
withdrawal 8 77.92 Quite High
analgesia 1 70.08 Quite High
cytokine 3 65.28 Quite High
fibrosis 4 56.32 Quite High
anesthesia 11 7.80 Low Low
COX2 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 187 100.00 Very High Very High Very High
Respiratory Syncytial Virus 396 99.96 Very High Very High Very High
Infection 360 98.96 Very High Very High Very High
Cv Unclassified Under Development 52 98.64 Very High Very High Very High
Cancer 230 98.60 Very High Very High Very High
INFLAMMATION 106 97.32 Very High Very High Very High
Targeted Disruption 99 97.04 Very High Very High Very High
Carcinoma 4 96.16 Very High Very High Very High
Von Hippel-lindau Syndrome 4 94.64 High High
Viral Infection 12 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This also allows us to investigate the effects of enhancing HIF-1 activity in the adult animal, avoiding any developmental effects, and modeling the potential use of HIF-1?
Localization (use) of HIF-1
1) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.59 Pain Relevance 0.05
Whole heart lysates were prepared as described above, and Western blot analysis was performed to determine protein abundance of HIF-1?
Spec (determine) Localization (abundance) of HIF-1 in heart
2) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.12 Pain Relevance 0.07
Western blotting of immunoprecipitated HIF-1?
Localization (immunoprecipitated) of HIF-1
3) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.17 Pain Relevance 0.07
We then evaluated the resulting cardiac phenotype and explored the underlying biochemical, physiological, and transcriptional results of HIF-1 stabilization.
Localization (stabilization) of HIF-1
4) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.77 Pain Relevance 0.08
Hypoxia and the subsequent stabilization of hypoxia inducible factor-1 (HIF-1) is one of the key initiators of (tumor-)angiogenesis as reviewed by Liao and Jonson [57].
Localization (stabilization) of hypoxia inducible factor-1 associated with cancer and hypoxia
5) Confidence 0.33 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.85 Pain Relevance 0.14
VHL cannot bind HIF-1 under hypoxic conditions, leading to stabilization of HIF-1 and downstream signaling [58].
Localization (stabilization) of HIF-1 associated with hypoxia
6) Confidence 0.33 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.73 Pain Relevance 0.12
Hypoxia and the subsequent stabilization of hypoxia inducible factor-1 (HIF-1) is one of the key initiators of (tumor-)angiogenesis as reviewed by Liao and Jonson [57].
Localization (stabilization) of HIF-1 associated with cancer and hypoxia
7) Confidence 0.33 Published 2010 Journal Angiogenesis Section Body Doc Link PMC2911541 Disease Relevance 0.85 Pain Relevance 0.14
From the present studies it remains unclear whether HIF-1?
Spec (unclear) Localization (unclear) of HIF-1
8) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.27 Pain Relevance 0.04
As first step, we performed immunohistochemical staining with antibodies for RSV (green) or HIF-1?
Localization (green) of HIF-1 associated with respiratory syncytial virus
9) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.49 Pain Relevance 0.15
, with localization of HIF-1?
Localization (localization) of HIF-1
10) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.65 Pain Relevance 0.13
Immunolocalization of HIF-1?
Localization (Immunolocalization) of HIF-1
11) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.10 Pain Relevance 0.15
The dimerization activates HIF-1 to translocate to the nucleus, bind DNA and promote expression of iNOS and other inflammatory genes [62–64].


Localization (translocate) of HIF-1 in nucleus associated with inflammation
12) Confidence 0.09 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386519 Disease Relevance 0.77 Pain Relevance 0.18

General Comments

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