INT232786

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.63
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Anatomy Link Frequency
nucleus 2
Hif1a (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 5 98.64 Very High Very High Very High
Inflammation 31 97.32 Very High Very High Very High
analgesia 1 70.08 Quite High
cytokine 3 65.68 Quite High
fibrosis 1 41.68 Quite Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
COX2 7 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 4 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 13 98.64 Very High Very High Very High
Respiratory Syncytial Virus 99 98.40 Very High Very High Very High
Infection 93 98.08 Very High Very High Very High
INFLAMMATION 40 97.32 Very High Very High Very High
Disease 4 91.92 High High
Sepsis 47 87.60 High High
Hypoxia 40 85.12 High High
Targeted Disruption 12 82.40 Quite High
Von Hippel-lindau Syndrome 1 80.00 Quite High
Cancer 5 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This also allows us to investigate the effects of enhancing HIF-1 activity in the adult animal, avoiding any developmental effects, and modeling the potential use of HIF-1?
Positive_regulation (enhancing) of Localization (use) of HIF-1
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908132 Disease Relevance 0.59 Pain Relevance 0.05
From the present studies it remains unclear whether HIF-1?
Spec (whether) Positive_regulation (whether) of Spec (unclear) Localization (unclear) of HIF-1
2) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 1.27 Pain Relevance 0.04
The dimerization activates HIF-1 to translocate to the nucleus, bind DNA and promote expression of iNOS and other inflammatory genes [62–64].


Positive_regulation (activates) of Localization (translocate) of HIF-1 in nucleus associated with inflammation
3) Confidence 0.06 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386519 Disease Relevance 0.77 Pain Relevance 0.18

General Comments

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