INT232795

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 11
Disease Relevance 3.68
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Shh) Golgi apparatus (Shh) endoplasmic reticulum (Shh)
embryo development (Shh) cell-cell signaling (Shh) signal transducer activity (Shh)
Anatomy Link Frequency
cornea 5
stroma 1
epithelium 1
Shh (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 60 97.32 Very High Very High Very High
Inflammation 4 87.00 High High
anesthesia 10 5.00 Very Low Very Low Very Low
Somatostatin 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
peptic ulcer disease 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinal Neovascularization 10 98.20 Very High Very High Very High
Burns 60 97.92 Very High Very High Very High
Hypoxia 10 96.56 Very High Very High Very High
Cancer 30 96.20 Very High Very High Very High
Skin Cancer 10 95.52 Very High Very High Very High
Malignant Neoplastic Disease 20 94.36 High High
Corneal Neovascularization 60 94.16 High High
Wound Healing 20 92.44 High High
Injury 70 92.04 High High
INFLAMMATION 3 87.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We detected upregulation of Shh in a healing stroma of an alkali-burned neovascularized mouse cornea, suggesting that Shh might have a role in the development of NV in a healing cornea.
Positive_regulation (upregulation) of Shh in cornea
1) Confidence 0.70 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.06 Pain Relevance 0
This report also shows that Shh activation is located upstream of VEGF in experimental retinal neovascularization under retinal hypoxic conditions because inhibition of the Shh pathway results in the reduction of VEGF level along with that of Patched-1 (Ptch1), a canonical Shh target.
Positive_regulation (activation) of Shh associated with hypoxia and retinal neovascularization
2) Confidence 0.70 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.34 Pain Relevance 0
Shh, but not the Ptc receptor, was upregulated in a vascularized healing mouse cornea post-alkali burn.
Positive_regulation (upregulated) of Shh in cornea associated with burns
3) Confidence 0.70 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.17 Pain Relevance 0
As previously reported by us [14], Shh was not detected in the corneal stroma of an uninjured cornea (data not shown) but was upregulated in both the healing epithelium and stroma (Figure 5A,C,E) until day 20.
Neg (not) Positive_regulation (upregulated) of Shh in epithelium
4) Confidence 0.70 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.34 Pain Relevance 0
We previously reported that Shh but not the Ptc Shh receptor is upregulated in the healing rat corneal epithelium post-debridement and that Shh promotes cell proliferation in the healing epithelium of a mouse cornea [14].
Positive_regulation (upregulated) of Shh receptor in cornea
5) Confidence 0.70 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.58 Pain Relevance 0.03
We previously reported that Shh but not the Ptc Shh receptor is upregulated in the healing rat corneal epithelium post-debridement and that Shh promotes cell proliferation in the healing epithelium of a mouse cornea [14].
Positive_regulation (upregulated) of Shh in cornea
6) Confidence 0.70 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.58 Pain Relevance 0.03
Shh did not affect the expression levels of angiogenic cytokines in cultured cell types. mRNA and protein expression levels of Shh and Ptc were under the detection limit in an uninjured cornea, but Shh but not Ptc was upregulated in a healing, alkali-burned, vascularized cornea.
Positive_regulation (upregulated) of Shh in cornea associated with cytokine
7) Confidence 0.47 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2684749 Disease Relevance 0.24 Pain Relevance 0.08
Immunohistochemistry showed that not only the nuclear translocation but also further induction of Shh in tissue were suppressed by topical treatment with cyclopamine (Figure 7D-G).


Positive_regulation (induction) of Shh
8) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.24 Pain Relevance 0
Upon Shh binding to the receptor composed of patched 1 (Ptc) and Smoothend (Smo), the Shh signal transmitter, Gli members, are activated and translocated to the cell nuclei for gene expression regulation.
Positive_regulation (activated) of Shh
9) Confidence 0.47 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.63 Pain Relevance 0.04
As previously reported by us [14], Shh was not detected in the corneal stroma of an uninjured cornea (data not shown) but was upregulated in both the healing epithelium and stroma (Figure 5A,C,E) until day 20.
Neg (not) Positive_regulation (upregulated) of Shh in stroma
10) Confidence 0.24 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.34 Pain Relevance 0
Furthermore, the expression level of Shh increased in the presence of gastric acid and showed a significant correlation with the gastric surface pH.
Positive_regulation (increased) of Shh
11) Confidence 0.14 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386521 Disease Relevance 0.16 Pain Relevance 0.08

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