INT232798

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.49
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Shh) Golgi apparatus (Shh) endoplasmic reticulum (Shh)
embryo development (Shh) cell-cell signaling (Shh) signal transducer activity (Shh)
Anatomy Link Frequency
mesenchyme 2
mesoderm 2
cornea 2
Shh (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 20 88.72 High High
Dopamine 83 88.44 High High
Inflammation 4 87.80 High High
chemokine 2 74.32 Quite High
cytokine 12 20.96 Low Low
Action potential 4 6.48 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Holoprosencephaly 2 99.92 Very High Very High Very High
Targeted Disruption 4 99.52 Very High Very High Very High
Burns 12 99.00 Very High Very High Very High
Cleidocranial Dysplasia 31 98.72 Very High Very High Very High
INFLAMMATION 3 87.80 High High
Injury 14 85.12 High High
Neurodegenerative Disease 7 80.16 Quite High
Nervous System Malformation 1 77.72 Quite High
Intellectual Impairment 2 73.92 Quite High
Corneal Neovascularization 12 61.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The exact mechanism of upregulation of Shh expression in a healing, injured cornea needs to be explored.
Positive_regulation (upregulation) of Gene_expression (expression) of Shh in cornea
1) Confidence 0.70 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.18 Pain Relevance 0
Moreover FGF10 beads can induce ectopic Shh expression, and Fgf10 knock-out mice lack rugae [10].
Positive_regulation (induce) of Gene_expression (expression) of Shh associated with targeted disruption
2) Confidence 0.66 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0.10 Pain Relevance 0
As previously mentioned, FGF signaling (from mesenchyme) probably participates in the induction and/or maintenance of Shh expression [10].
Positive_regulation (maintenance) of Gene_expression (expression) of Shh in mesenchyme
3) Confidence 0.44 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2637861 Disease Relevance 0 Pain Relevance 0
Four treatment groups were prepared: 1) control without exogenous agents; 2) a polymer pellet containing recombinant Shh (50 ?
Positive_regulation (pellet) of Gene_expression (containing) of Shh
4) Confidence 0.44 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.11 Pain Relevance 0
The authors proposed that the phenotype was due to two position effect mutations, one at each breakpoint, altering the expression of the SHH (holoprosencephaly) and RUNX2 (CCD) genes.
Positive_regulation (altering) of Gene_expression (expression) of SHH associated with cleidocranial dysplasia and holoprosencephaly
5) Confidence 0.36 Published 2008 Journal American Journal of Medical Genetics. Part a Section Body Doc Link PMC2663417 Disease Relevance 0.77 Pain Relevance 0
Nonetheless the introduction of FGF10 to chick embryos up-regulated FGF8 expression in the ectoderm through Wnt3a signaling and stimulated SHH expression in the posterior mesoderm followed by outgrowth initiation of chick limb structures [48], [49].
Positive_regulation (stimulated) of Gene_expression (expression) of SHH in mesoderm
6) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0.16 Pain Relevance 0.35
Furthermore, the expression level of Shh increased in the presence of gastric acid and showed a significant correlation with the gastric surface pH.
Positive_regulation (increased) of Gene_expression (expression) of Shh
7) Confidence 0.22 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386521 Disease Relevance 0.17 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox