INT232799

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.04
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Shh) Golgi apparatus (Shh) endoplasmic reticulum (Shh)
embryo development (Shh) cell-cell signaling (Shh) signal transducer activity (Shh)
Anatomy Link Frequency
cornea 4
ventral 2
Shh (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 12 99.16 Very High Very High Very High
Inflammation 4 78.80 Quite High
imagery 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Somatostatin 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
local anesthetic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Burns 13 87.40 High High
Corneal Neovascularization 12 86.96 High High
Wound Healing 4 79.20 Quite High
INFLAMMATION 3 78.80 Quite High
Medulloblastoma 30 67.44 Quite High
Basal Cell Carcinoma 46 66.60 Quite High
Basal Cell Nevus Syndrome 88 65.20 Quite High
Cancer 47 59.76 Quite High
Retinoblastoma 3 56.64 Quite High
Syndrome 44 52.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Shh did not affect the expression levels of angiogenic cytokines in cultured cell types. mRNA and protein expression levels of Shh and Ptc were under the detection limit in an uninjured cornea, but Shh but not Ptc was upregulated in a healing, alkali-burned, vascularized cornea.
Regulation (under) of Gene_expression (expression) of Shh in cornea associated with cytokine
1) Confidence 0.27 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2684749 Disease Relevance 0.25 Pain Relevance 0.09
The expression level of Shh mRNA was under the detection limit in the uninjured cornea while Shh mRNA expression was certainly detected at a markedly high level (approximately 227 fold compared with control) in an alkali-burned cornea.
Regulation (under) of Gene_expression (expression) of Shh mRNA in cornea
2) Confidence 0.27 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2684749 Disease Relevance 0.17 Pain Relevance 0
SHH is a true signaling switch used in differentiating subpopulations of cells throughout the embryo; in fact, SHH patterning is involved in several embryonal processes, such as the formation of the ventral neural tube (basal plate, motor columns), the limb bud, parts of the brain, hair follicle development, and tooth development.
Regulation (involved) of Gene_expression (patterning) of SHH in ventral
3) Confidence 0.15 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2607262 Disease Relevance 0.48 Pain Relevance 0
These results suggest that suppressed gastric acid secretion alone may be sufficient to down-regulate Shh expression.
Regulation (regulate) of Gene_expression (expression) of Shh
4) Confidence 0.14 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386521 Disease Relevance 0.15 Pain Relevance 0.07

General Comments

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