INT23280

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Context Info
Confidence 0.05
First Reported 1985
Last Reported 1985
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.53
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PRSS1, Penk) peptidase activity (PRSS1) extracellular space (PRSS1)
PRSS1 (Homo sapiens)
Penk (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 32 100.00 Very High Very High Very High
Catecholamine 6 84.72 Quite High
Endogenous opioid 2 70.12 Quite High
Opioid 4 48.24 Quite Low
antagonist 2 47.68 Quite Low
Disease Link Frequency Relevance Heat
Cancer 10 100.00 Very High Very High Very High
Pheochromocytoma 14 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The amount of enkephalin immunoreactivity present initially in these tumors was greatly augmented by the prohormone activators trypsin or trypsin plus carboxypeptidase B, suggesting that most of the immunoreactive enkephalin was present in higher molecular weight precursor form.
trypsin Positive_regulation (augmented) of enkephalin associated with cancer and enkephalin
1) Confidence 0.05 Published 1985 Journal Clin Exp Hypertens A Section Abstract Doc Link 2408793 Disease Relevance 0.77 Pain Relevance 1.37
The amount of enkephalin immunoreactivity present initially in these tumors was greatly augmented by the prohormone activators trypsin or trypsin plus carboxypeptidase B, suggesting that most of the immunoreactive enkephalin was present in higher molecular weight precursor form.
trypsin Positive_regulation (augmented) of enkephalin associated with cancer and enkephalin
2) Confidence 0.05 Published 1985 Journal Clin Exp Hypertens A Section Abstract Doc Link 2408793 Disease Relevance 0.76 Pain Relevance 1.37

General Comments

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