INT232821

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.38
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Krt18) microtubule organizing center (Krt18) cytoplasm (Krt18)
Anatomy Link Frequency
liver 2
Krt18 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 77 81.92 Quite High
Bile 27 80.44 Quite High
alcohol 27 43.84 Quite Low
Paracetamol 37 5.00 Very Low Very Low Very Low
Inflammation 28 5.00 Very Low Very Low Very Low
Potency 9 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 138 100.00 Very High Very High Very High
Aging 20 95.12 Very High Very High Very High
Stress 162 94.36 High High
Liver Disease 137 91.24 High High
Nash(non-alcoholic Steatohepatitis) 63 87.96 High High
Parkinson's Disease 9 86.92 High High
Cancer 183 85.12 High High
Chronic Hepatitis 36 83.32 Quite High
Cirrhosis 76 81.92 Quite High
Hepatotoxicity 18 80.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cell culture experiments, protein aggregates resembling MDBs formed only after p62 co-transfection, but not when K8, K18, and ubiquitin were transfected alone or in combination (Stumptner et al. 2007).
Positive_regulation (transfected) of Gene_expression (transfected) of K18
1) Confidence 0.50 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.17 Pain Relevance 0
Dysbalanced K8/K18 expression precedes MDB formation, likely increases keratin misfolding and predisposes to posttranslational modifications, which may interfere with keratin refolding and/or repair.
Positive_regulation (increases) of Gene_expression (expression) of K18
2) Confidence 0.41 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.30 Pain Relevance 0
MDBs also arise in cell culture after transfection with K8/K18, ubiquitin, and p62.
Positive_regulation (transfection) of Gene_expression (transfection) of K18
3) Confidence 0.41 Published 2008 Journal Histochem Cell Biol Section Abstract Doc Link PMC2386529 Disease Relevance 1.00 Pain Relevance 0.04
Griseofulvin/DDC feeding leads to rapid induction of K8/K18 expression with disproportional K8 > K18 levels (Denk et al. 2000).
Positive_regulation (induction) of Gene_expression (expression) of K18
4) Confidence 0.41 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.71 Pain Relevance 0
Several pathogenic mechanisms were implicated in this process (Fig. 4; Dobson 2004):1.Enhanced oxidative stress2.Disproportional K8/K18 expression together with keratin modifications3.Chaperone dysfunction4.Elevated p62 levels5.Insufficient protein degradation
Positive_regulation (1.Enhanced) of Gene_expression (expression) of K18
5) Confidence 0.41 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.22 Pain Relevance 0.08
Several pathogenic mechanisms were implicated in this process (Fig. 4; Dobson 2004):1.Enhanced oxidative stress2.Disproportional K8/K18 expression together with keratin modifications3.Chaperone dysfunction4.Elevated p62 levels5.Insufficient protein degradation
Positive_regulation (dysfunction4.Elevated) of Gene_expression (expression) of K18
6) Confidence 0.41 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.23 Pain Relevance 0.08
Several pathogenic mechanisms were implicated in this process (Fig. 4; Dobson 2004):1.Enhanced oxidative stress2.Disproportional K8/K18 expression together with keratin modifications3.Chaperone dysfunction4.Elevated p62 levels5.Insufficient protein degradation
Positive_regulation (oxidative) of Gene_expression (expression) of K18
7) Confidence 0.41 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.22 Pain Relevance 0.08
As visualized by IF-staining, the G-2 cell pattern of cytokeratin expression was reproduced in G-2 cell derived clones (Figure S1A–B; shown as example for clones G-2C9 and G-2C11), although according to qPCR analysis the relative levels of Krt14 and Krt18 gene expression varied markedly between clones (Figure S1C–D).
Positive_regulation (varied) of Gene_expression (expression) of Krt18
8) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.14 Pain Relevance 0
However, the exclusive MDB inducing property of K8 in vivo cannot be reproduced in vitro, where aggregates resembling MDBs can also be produced by transfection of K18 (Nakamichi et al. 2002; Stumptner et al. 2007).
Positive_regulation (transfection) of Gene_expression (transfection) of K18
9) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.46 Pain Relevance 0
The elevated K8/K18 ratio is crucial for MDB formation as shown in K18-knockout and K8 overexpressing animals, who are predisposed to MDB formation already upon short exposure to DDC and even form MDBs spontaneously during aging (Magin et al. 1998; Nakamichi et al. 2005).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of K18-knockout associated with targeted disruption and aging
10) Confidence 0.36 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.70 Pain Relevance 0
In accordance to this, RT-PCR on liver samples showed that neither CK18, cytochrome P450 (CYP3A4) (data not shown), ?
Positive_regulation (accordance) of Gene_expression (showed) of CK18 in liver
11) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722022 Disease Relevance 0.23 Pain Relevance 0.03

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