INT232828

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.20
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Krt18) microtubule organizing center (Krt18) cytoplasm (Krt18)
Anatomy Link Frequency
liver 1
Krt18 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 24 95.24 Very High Very High Very High
Paracetamol 12 64.40 Quite High
Potency 3 62.60 Quite High
Bile 9 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
alcohol 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 42 98.60 Very High Very High Very High
Chronic Hepatitis 12 97.12 Very High Very High Very High
Liver Disease 45 96.08 Very High Very High Very High
Cirrhosis 24 95.24 Very High Very High Very High
Aging 6 93.80 High High
Apoptosis 69 71.04 Quite High
Injury 21 69.44 Quite High
Nash(non-alcoholic Steatohepatitis) 21 69.12 Quite High
Stress 54 68.64 Quite High
Parkinson's Disease 3 68.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accordingly, K8-null or K18 overexpressing mice are resistant to MDB formation and the protective function of K18 is not affected by its phosphorylation status or mutation (Zatloukal et al. 2000; Harada et al. 2007).
Neg (not) Regulation (affected) of K18
1) Confidence 0.50 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.56 Pain Relevance 0
K8/K18 variants may also affect organelle function, as seen in K8 knockout mice, which exhibit altered mitochondrial shape, localization, and alterations in several mitochondrial proteins (Toivola et al. 2005).
Spec (may) Regulation (affect) of K18 associated with targeted disruption
2) Confidence 0.37 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.65 Pain Relevance 0.13
K8 R340H represents the most common amino acid altering K8/K18 variant and it is the only one, which was significantly associated with development of end-stage liver disease (Ku et al. 2005).
Regulation (altering) of K18 in liver associated with liver disease
3) Confidence 0.32 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 1.00 Pain Relevance 0.13

General Comments

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