INT232828
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Accordingly, K8-null or K18 overexpressing mice are resistant to MDB formation and the protective function of K18 is not affected by its phosphorylation status or mutation (Zatloukal et al. 2000; Harada et al. 2007). | |||||||||||||||
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K8/K18 variants may also affect organelle function, as seen in K8 knockout mice, which exhibit altered mitochondrial shape, localization, and alterations in several mitochondrial proteins (Toivola et al. 2005). | |||||||||||||||
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K8 R340H represents the most common amino acid altering K8/K18 variant and it is the only one, which was significantly associated with development of end-stage liver disease (Ku et al. 2005). | |||||||||||||||
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