INT232828

Context Info Confidence 0.50 First Reported 2008 Last Reported 2008 Negated 1 Speculated 1 Reported most in Body Documents 1 Total Number 3 Disease Relevance 2.20 Pain Relevance 0.26

structural molecule activity (Krt18) microtubule organizing center (Krt18) cytoplasm (Krt18)

Anatomy Link Frequency liver 1 Krt18 (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 24 95.24 Paracetamol 12 64.40 Potency 3 62.60 Bile 9 5.00 Inflammation 9 5.00 alcohol 9 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 42 98.60 Chronic Hepatitis 12 97.12 Liver Disease 45 96.08 Cirrhosis 24 95.24 Aging 6 93.80 Apoptosis 69 71.04 Injury 21 69.44 Nash(non-alcoholic Steatohepatitis) 21 69.12 Stress 54 68.64 Parkinson's Disease 3 68.08

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Accordingly, K8-null or K18 overexpressing mice are resistant to MDB formation and the protective function of K18 is not affected by its phosphorylation status or mutation (Zatloukal et al. 2000; Harada et al. 2007).

Neg (not) Regulation (affected) of K18

1) Confidence 0.50 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.56 Pain Relevance 0

K8/K18 variants may also affect organelle function, as seen in K8 knockout mice, which exhibit altered mitochondrial shape, localization, and alterations in several mitochondrial proteins (Toivola et al. 2005).

Spec (may) Regulation (affect) of K18 associated with targeted disruption

2) Confidence 0.37 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.65 Pain Relevance 0.13

K8 R340H represents the most common amino acid altering K8/K18 variant and it is the only one, which was significantly associated with development of end-stage liver disease (Ku et al. 2005).

Regulation (altering) of K18 in liver associated with liver disease

3) Confidence 0.32 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 1.00 Pain Relevance 0.13

General Comments

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