INT232830

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.75
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Nup62) nuclear envelope (Nup62) cell death (Nup62)
cytoskeleton (Nup62) nucleus (Nup62) cytoplasm (Nup62)
Nup62 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 6 76.04 Quite High
alcohol 6 39.44 Quite Low
fibrosis 16 5.00 Very Low Very Low Very Low
Paracetamol 8 5.00 Very Low Very Low Very Low
Spinal cord 7 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 39 92.48 High High
Death 7 87.00 High High
Neuroblastoma 1 60.88 Quite High
Dementia 15 58.76 Quite High
Motor Neuron Diseases 62 50.00 Quite Low
Recurrence 2 41.72 Quite Low
Porphyria 2 41.28 Quite Low
End Stage Liver Disease 2 33.08 Quite Low
Injury 18 29.92 Quite Low
Gallstones 8 29.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several pathogenic mechanisms were implicated in this process (Fig. 4; Dobson 2004):1.Enhanced oxidative stress2.Disproportional K8/K18 expression together with keratin modifications3.Chaperone dysfunction4.Elevated p62 levels5.Insufficient protein degradation
Positive_regulation (dysfunction4.Elevated) of Protein_catabolism (degradation) of p62
1) Confidence 0.39 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.23 Pain Relevance 0.08
Several pathogenic mechanisms were implicated in this process (Fig. 4; Dobson 2004):1.Enhanced oxidative stress2.Disproportional K8/K18 expression together with keratin modifications3.Chaperone dysfunction4.Elevated p62 levels5.Insufficient protein degradation
Positive_regulation (dysfunction4.Elevated) of Protein_catabolism (degradation) of p62
2) Confidence 0.28 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.23 Pain Relevance 0.08
10 results in increased levels of ubiquitin and p62 and inhibition of protein degradation through the process of autophagy [13].
Positive_regulation (increased) of Protein_catabolism (degradation) of p62
3) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.29 Pain Relevance 0

General Comments

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