INT232832

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.84
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Krt8) nucleus (Krt8) cytoplasm (Krt8)
Anatomy Link Frequency
nucleus 1
Krt8 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 16 5.00 Very Low Very Low Very Low
Paracetamol 8 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 4 99.00 Very High Very High Very High
Targeted Disruption 28 97.28 Very High Very High Very High
Apoptosis 46 95.32 Very High Very High Very High
Injury 14 81.88 Quite High
Malignant Neoplastic Disease 2 73.20 Quite High
Disease 34 72.40 Quite High
Alcoholic Liver Diseases 2 45.76 Quite Low
Stress 36 40.80 Quite Low
Aging 4 29.08 Quite Low
Liver Disease 30 20.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The former class constitutes established tumor markers such as tissue polypeptide antigen (TPA, represents total K8/K18/K19), tissue polypeptide specific antigen (TPS, derived from K18), and CYtokeratin FRAgment 21-1 (CYFRA 21-1, derived from K19).
Localization (represents) of K8 associated with cancer
1) Confidence 0.48 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.69 Pain Relevance 0
Since K8 is a much better in vitro transglutaminase substrate than K18 and highly cross-linked proteins found in MDB-forming mice contain K8, but not K18, it was suggested that excessive K8 gets preferentially transamidated and acts as a nucleus for MDB formation.
Localization (formation) of K8 in nucleus
2) Confidence 0.42 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.15 Pain Relevance 0

General Comments

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