INT232833

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.79
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp2a5)
Cyp2a5 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 4 79.52 Quite High
Paracetamol 6 21.28 Low Low
depression 8 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 47 89.16 High High
Nash(non-alcoholic Steatohepatitis) 7 76.40 Quite High
Disease 20 73.92 Quite High
Newborn Jaundice 1 72.92 Quite High
Drug Induced Neurotoxicity 1 72.08 Quite High
Toxicity 1 68.24 Quite High
Hepatotoxicity 2 52.40 Quite High
Malaria 45 50.00 Quite Low
Injury 12 47.40 Quite Low
Parkinson's Disease 1 41.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the authors pointed out that the foregoing CYP2a5 inducers also up-regulated HO-1, and that CYP2a5 over-expression is often associated with a decrease of total CYP content, which in turn has been shown to be associated with HO-1 induction as well.
Positive_regulation (over) of Gene_expression (expression) of CYP2a5
1) Confidence 0.38 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.35 Pain Relevance 0.04
Moreover, Cyp2e5 overexpression spacially coincides with MDB formation (Zatloukal et al., unpublished data).
Positive_regulation (overexpression) of Gene_expression (overexpression) of Cyp2e5
2) Confidence 0.01 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.44 Pain Relevance 0

General Comments

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