INT232834

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.80
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Nup62) nuclear envelope (Nup62) cell death (Nup62)
cytoskeleton (Nup62) nucleus (Nup62) cytoplasm (Nup62)
Nup62 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 3 75.16 Quite High
alcohol 3 38.56 Quite Low
cytokine 8 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Spinal cord 7 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
midbrain 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 37 98.20 Very High Very High Very High
Stress 21 92.48 High High
Death 5 85.64 High High
Neuroblastoma 1 59.52 Quite High
Dementia 15 57.40 Quite High
Motor Neuron Diseases 62 50.00 Quite Low
Gastritis 7 50.00 Quite Low
Porphyria 1 41.28 Quite Low
Recurrence 1 40.84 Quite Low
End Stage Liver Disease 1 32.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several pathogenic mechanisms were implicated in this process (Fig. 4; Dobson 2004):1.Enhanced oxidative stress2.Disproportional K8/K18 expression together with keratin modifications3.Chaperone dysfunction4.Elevated p62 levels5.Insufficient protein degradation
Protein_catabolism (degradation) of p62
1) Confidence 0.56 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.23 Pain Relevance 0.07
10 results in increased levels of ubiquitin and p62 and inhibition of protein degradation through the process of autophagy [13].
Protein_catabolism (degradation) of p62
2) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.29 Pain Relevance 0
The p62 was induced at 2 h p.i., and degrade gradually till 24 h, p.i., indicating that an autophagic flux was induced post infection.
Protein_catabolism (degrade) of p62 associated with infection
3) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877707 Disease Relevance 0.29 Pain Relevance 0

General Comments

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