INT232835

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.71
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Krt18) microtubule organizing center (Krt18) cytoplasm (Krt18)
Krt18 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 8 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 14 98.60 Very High Very High Very High
Aging 2 92.52 High High
Nash(non-alcoholic Steatohepatitis) 7 84.28 Quite High
Parkinson's Disease 1 83.24 Quite High
Stress 18 78.92 Quite High
Hepatotoxicity 2 77.20 Quite High
Apoptosis 23 5.00 Very Low Very Low Very Low
Disease 17 5.00 Very Low Very Low Very Low
Liver Disease 15 5.00 Very Low Very Low Very Low
Acute Liver Failure 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The elevated K8/K18 ratio is crucial for MDB formation as shown in K18-knockout and K8 overexpressing animals, who are predisposed to MDB formation already upon short exposure to DDC and even form MDBs spontaneously during aging (Magin et al. 1998; Nakamichi et al. 2005).
Regulation (crucial) of Positive_regulation (elevated) of K18 associated with targeted disruption and aging
1) Confidence 0.37 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.71 Pain Relevance 0

General Comments

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