INT232835

Context Info Confidence 0.37 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.71 Pain Relevance 0

structural molecule activity (Krt18) microtubule organizing center (Krt18) cytoplasm (Krt18)

Krt18 (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 8 5.00 Paracetamol 4 5.00 Bile 3 5.00 Inflammation 3 5.00 alcohol 3 5.00 Potency 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 14 98.60 Aging 2 92.52 Nash(non-alcoholic Steatohepatitis) 7 84.28 Parkinson's Disease 1 83.24 Stress 18 78.92 Hepatotoxicity 2 77.20 Apoptosis 23 5.00 Disease 17 5.00 Liver Disease 15 5.00 Acute Liver Failure 9 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The elevated K8/K18 ratio is crucial for MDB formation as shown in K18-knockout and K8 overexpressing animals, who are predisposed to MDB formation already upon short exposure to DDC and even form MDBs spontaneously during aging (Magin et al. 1998; Nakamichi et al. 2005).

Regulation (crucial) of Positive_regulation (elevated) of K18 associated with targeted disruption and aging

1) Confidence 0.37 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.71 Pain Relevance 0

General Comments

This test has worked.