INT23284

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Context Info
Confidence 0.58
First Reported 1980
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 1.84
Pain Relevance 4.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Gpi) carbohydrate metabolic process (Gpi) cytoplasm (Gpi)
cytosol (Gpi) extracellular space (Gpi) extracellular region (Gpi)
Anatomy Link Frequency
neuronal 1
projection neurons 1
Blood vessels 1
basal ganglia 1
cortex 1
Gpi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 635 100.00 Very High Very High Very High
substance P 14 99.56 Very High Very High Very High
positron emission tomography 29 99.04 Very High Very High Very High
Thalamus 47 98.40 Very High Very High Very High
projection neuron 10 97.96 Very High Very High Very High
Morphine 4 97.44 Very High Very High Very High
dopamine receptor 175 97.20 Very High Very High Very High
narcan 4 96.40 Very High Very High Very High
GABAergic 110 96.04 Very High Very High Very High
agonist 146 93.28 High High
Disease Link Frequency Relevance Heat
Dyskinesias 43 99.52 Very High Very High Very High
Disease 173 99.36 Very High Very High Very High
Parkinson's Disease 149 98.12 Very High Very High Very High
Targeted Disruption 12 87.12 High High
Depression 6 76.72 Quite High
Congenital Anomalies 13 65.92 Quite High
Urological Neuroanatomy 12 20.44 Low Low
Attention Deficit Hyperactivity Disorder 18 5.00 Very Low Very Low Very Low
Movement Disorders 13 5.00 Very Low Very Low Very Low
Cognitive Disorder 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nalozone treatment alone, to both intact and ovariectomized/adrenalectomized animals, resulted in stimulation of PFK and inhibition of PHI activities.
Negative_regulation (inhibition) of PHI
1) Confidence 0.58 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 6447740 Disease Relevance 0 Pain Relevance 1.02
Current models of LID suggest that excessive decrease in GPi activity in turn disinhibits the motor thalamus and the cortex, giving rise to abnormal increase in cortical drive and consequent excessive motor movements (Wichmann and DeLong, 1996; Bezard et al., 2001a).
Negative_regulation (decrease) of GPi in cortex associated with thalamus and dyskinesias
2) Confidence 0.25 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.51 Pain Relevance 0.29
Overall, dopamine appears to decrease the neuronal activity in the GPi, likely via activation of D1LRs (Table 2).
Spec (likely) Negative_regulation (decrease) of GPi in neuronal associated with dopamine
3) Confidence 0.21 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.09 Pain Relevance 0.24
As mentioned above, PET studies in humans have suggested that dopamine loss in the GPi may be involved in some of the early compensatory changes in PD (Whone et al., 2003).
Negative_regulation (loss) of GPi associated with dopamine, positron emission tomography and disease
4) Confidence 0.21 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.28 Pain Relevance 0.52
While there is evidence of dopamine loss in the GPi of humans with PD (Hornykiewicz, 1998) and of MPTP-treated monkeys (Pifl et al., 1990), the behavioral consequences of this loss are not fully understood.
Negative_regulation (loss) of GPi associated with parkinson's disease, dopamine and disease
5) Confidence 0.16 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.27 Pain Relevance 0.40
Studies in human subjects have indicated that decreased dopamine levels in GPi, as measured with raclopride displacement positron emission tomography (PET), were associated with faster motor learning (Garraux et al., 2007).
Negative_regulation (decreased) of GPi associated with dopamine and positron emission tomography
6) Confidence 0.16 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.30 Pain Relevance 0.43
The view that D1LR and D2LR effects are in some sense similar is obviously simplistic, but it may result in the recognition of overall response patterns of neurons in these nuclei to endogenous dopamine: the activity of GPe and STN neurons appears to be increased, while the activity of the basal ganglia output nuclei, GPi and SNr, appears to be reduced.
Negative_regulation (reduced) of GPi in basal ganglia associated with dopamine
7) Confidence 0.16 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.24 Pain Relevance 0.40
Blood vessels received a rich supply of NPY fibers; the number of perivascular VIP/PHI, GRP, and SP fibers was much lower by comparison.
Negative_regulation (number) of PHI in Blood vessels associated with substance p
8) Confidence 0.10 Published 1985 Journal Gastroenterology Section Abstract Doc Link 2408958 Disease Relevance 0 Pain Relevance 0.67
According to traditional models of the basal ganglia, the dopamine-mediated increase in activity of the inhibitory direct pathway, in conjunction with the dopamine-mediated reduction of activity in the net excitatory indirect pathway leads to an overall reduction of activity of GPi/SNr neurons, acting to disinhibit thalamocortical projection neurons.
Negative_regulation (reduction) of GPi in projection neurons associated with dopamine and projection neuron
9) Confidence 0.08 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.15 Pain Relevance 0.37
The mucosa harbored numerous GRP fibers and VIP/PHI (rat) or VIP/PHI/NPY (mouse) fibers, and a modest number of NPY (rat) and SP fibers.
Negative_regulation (harbored) of PHI associated with substance p
10) Confidence 0.05 Published 1985 Journal Gastroenterology Section Abstract Doc Link 2408958 Disease Relevance 0 Pain Relevance 0.62

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