INT232841

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 11
Total Number 28
Disease Relevance 8.68
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Scap) endoplasmic reticulum (Scap) protein complex (Scap)
lipid metabolic process (Scap)
Anatomy Link Frequency
brain 5
Atlas 2
neuronal 1
liver 1
neural 1
Scap (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 123 93.28 High High
dopamine receptor 18 79.76 Quite High
Bile 9 78.36 Quite High
midbrain 144 68.04 Quite High
imagery 23 65.36 Quite High
medulla 72 58.52 Quite High
Hippocampus 82 57.84 Quite High
ischemia 41 55.84 Quite High
addiction 8 50.00 Quite Low
Inflammatory stimuli 3 48.36 Quite Low
Disease Link Frequency Relevance Heat
Stress 393 100.00 Very High Very High Very High
Disease 389 100.00 Very High Very High Very High
Shock 862 99.52 Very High Very High Very High
Neurodegenerative Disease 124 98.70 Very High Very High Very High
Apoptosis 150 98.56 Very High Very High Very High
INFLAMMATION 117 93.28 High High
Cancer 35 92.36 High High
Injury 35 91.48 High High
Alcoholic Liver Diseases 3 88.24 High High
Targeted Disruption 105 82.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is abundant evidence for the increased expression of chaperone gene expression under conditions that also increase oxidative stress [5,45].
Gene_expression (expression) of chaperone associated with stress
1) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.90 Pain Relevance 0
What might the increased levels of chaperone proteins be doing in the liver after WY exposure?
Gene_expression (levels) of chaperone in liver
2) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.29 Pain Relevance 0
Chaperone protein expression after heat shock and WY treatment
Gene_expression (expression) of Chaperone associated with shock
3) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.73 Pain Relevance 0
There is abundant evidence for the increased expression of chaperone gene expression under conditions that also increase oxidative stress [5,45].
Gene_expression (expression) of chaperone associated with stress
4) Confidence 0.02 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.90 Pain Relevance 0
The protein misfolding is usually counteracted by the reparative function of chaperones (Ross and Poirier 2004; Macario and Conway de Macario 2005; Bukau et al. 2006), however, DDC feeding is associated with diminished chaperone expression, persistent chaperone modifications and impairment of chaperone function (Strnad et al. submitted).
Gene_expression (expression) of chaperone
5) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.25 Pain Relevance 0
The protein misfolding is usually counteracted by the reparative function of chaperones (Ross and Poirier 2004; Macario and Conway de Macario 2005; Bukau et al. 2006), however, DDC feeding is associated with diminished chaperone expression, persistent chaperone modifications and impairment of chaperone function (Strnad et al. submitted).
Gene_expression (expression) of chaperone
6) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.25 Pain Relevance 0
Several pathogenic mechanisms were implicated in this process (Fig. 4; Dobson 2004):1.Enhanced oxidative stress2.Disproportional K8/K18 expression together with keratin modifications3.Chaperone dysfunction4.Elevated p62 levels5.Insufficient protein degradation
Gene_expression (expression) of Chaperone
7) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.22 Pain Relevance 0.08
From our analysis of the chaperone expression data in ABA we can identify about 30 genes in the ABA that show a significant degree of variability in levels across different structures of the brain (Table 1, Figure 11, Table S3).
Gene_expression (expression) of chaperone in brain
8) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0 Pain Relevance 0.05
We determined that 256 of these chaperone genes are expressed at some level.
Gene_expression (expressed) of chaperone
9) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965669 Disease Relevance 0.22 Pain Relevance 0
In the present study, we focus on characterization of the pattern of chaperone expression in specific substructures of the normal adult murine brain.
Gene_expression (expression) of chaperone in brain
10) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.21 Pain Relevance 0
Notably, relatively few genes of the total chaperone network are ubiquitously expressed at high levels (Table 2, Table S2).
Gene_expression (expressed) of chaperone
11) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.09 Pain Relevance 0
The expression pattern of these genes shows considerably more variability than the chaperone genes (Figure 2).
Gene_expression (expression) of chaperone
12) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.47 Pain Relevance 0.05
About one-third of the genes of the chaperone network are expressed at low levels or not at all across the entire brain.
Neg (not) Gene_expression (expressed) of chaperone in brain
13) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.08 Pain Relevance 0.05
However, for each of these chaperone/co-chaperone systems, we observe relatively little variation in the expression levels of the chaperone component.
Gene_expression (expression) of chaperone
14) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0 Pain Relevance 0
Our analysis provides a valuable resource towards determining how variations in chaperone gene expression may modulate the vulnerability of specific neuronal populations of mammalian brain.



Gene_expression (expression) of chaperone in neuronal
15) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965669 Disease Relevance 0.14 Pain Relevance 0
Although there are several published studies in which transcriptional profiling has been used to examine gene expression in various tissues, including tissues of neurodegenerative disease models, there has not been a report that focuses exclusively on expression of the chaperone network.
Gene_expression (expression) of chaperone associated with neurodegenerative disease
16) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965669 Disease Relevance 0.25 Pain Relevance 0
In the present study, we used the Allen Brain Atlas online database to analyze chaperone expression levels.
Spec (analyze) Gene_expression (expression) of chaperone in Atlas
17) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965669 Disease Relevance 0.24 Pain Relevance 0
Given the plethora of data provided by the ABA, it would make sense to use an in situ hybridization identical to the protocols detailed on the website as at least one approach to characterize how a specific compound or insult affects expression of the chaperone network.


Gene_expression (expression) of chaperone
18) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.25 Pain Relevance 0
Previous studies have performed gene expression analysis of normal and diseased mouse CNS tissue which provide some clues to regional chaperone expression [16]–[25].
Gene_expression (expression) of chaperone
19) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.40 Pain Relevance 0
Our aim was to establish a baseline expression of the chaperone network to provide a framework to explore the basis for neural vulnerability.
Gene_expression (expression) of chaperone in neural
20) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.20 Pain Relevance 0

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