INT232842

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Context Info
Confidence 0.66
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 5.81
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Tnfaip8)
Anatomy Link Frequency
macrophages 2
blood 1
liver 1
Tnfaip8 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 11 98.04 Very High Very High Very High
cytokine 503 97.72 Very High Very High Very High
metalloproteinase 5 96.88 Very High Very High Very High
Inflammation 76 92.72 High High
Inflammatory response 41 85.40 High High
chemokine 67 65.64 Quite High
Paracetamol 4 49.28 Quite Low
Pain 26 5.00 Very Low Very Low Very Low
Arthritis 13 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 70 100.00 Very High Very High Very High
Cardiomyopathy 3 100.00 Very High Very High Very High
Cirrhosis 8 98.28 Very High Very High Very High
Infection 717 96.28 Very High Very High Very High
Rupture 1 93.40 High High
INFLAMMATION 90 92.72 High High
Communicable Diseases 39 90.32 High High
Sprains And Strains 781 88.32 High High
Targeted Disruption 34 87.72 High High
Pneumonia 13 87.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ten genes (March3, Cep120, Chmp1b, Dcp2, Dtwd2, Isoc1, Lman1, Spire1, Tnfaip8, and Seh1l) mapped to the two significant QTLs and were differentially expressed between A/J and C57BL/6J.
Gene_expression (expressed) of Tnfaip8
1) Confidence 0.66 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2932726 Disease Relevance 0.90 Pain Relevance 0.09
A total of 10 genes (March3, Cep120, Chmp1b, Dcp2, Dtwd2, Isoc1, Lman1, Spire1, Tnfaip8, and Seh1l) mapping within our two significant QTLs were differentially expressed between S. aureus infected A/J and C57BL/6J mice.
Gene_expression (expressed) of Tnfaip8
2) Confidence 0.66 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0.27 Pain Relevance 0
Compared to S. aureus-challenged negative controls, S. aureus-challenged cells with knockdown expression of Tnfaip8 produced a significantly lower level of IL-1?
Gene_expression (expression) of Tnfaip8
3) Confidence 0.66 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0.15 Pain Relevance 0.24
More notably, knockdown expression of two of the six genes, Tnfaip8 and Seh1l, significantly altered the specific patterns of cytokine production in S. aureus- stimulated RAW cells in a manner that was also observed in PM?
Gene_expression (expression) of Tnfaip8 associated with cytokine
4) Confidence 0.66 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0.27 Pain Relevance 0.30
For example, K18 R89C mice are predisposed to Fas but not TNF-induced apoptosis and the same mice develop more pronounced liver fibrosis after thioacetamide, but not after carbon tetrachloride injection (Ku et al. 2003b; Strnad et al. 2008).
Neg (not) Gene_expression (apoptosis) of TNF-induced in liver associated with fibrosis, cirrhosis and apoptosis
5) Confidence 0.65 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.60 Pain Relevance 0.05
In a model of TNF-induced cardiomyopathy through cardiac-specific TNFalpha expression, p50 KO mice had improved diastolic and systolic function, suppressed matrix metalloproteinase activity and expression, and improved survival in male mice [53].
Gene_expression (expression) of TNF-induced associated with cardiomyopathy and metalloproteinase
6) Confidence 0.65 Published 2010 Journal Heart Fail Rev Section Body Doc Link PMC3003782 Disease Relevance 0.52 Pain Relevance 0.21
For two (Tnfaip8 and Seh1l) of these 6 genes, siRNA-mediated knockdown of gene expression in S. aureus–challenged RAW264.7 macrophages induced significant changes in the cytokine response (IL-1 ?
Gene_expression (two) of Tnfaip8 in macrophages associated with cytokine
7) Confidence 0.58 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2932726 Disease Relevance 0.45 Pain Relevance 0.09
The TNFAIP8 family of proteins consists of TNFAIP8, TIPE1 (TNFAIP8Like1), TIPE2 and TIPE3.
Gene_expression (family) of TNFAIP8
8) Confidence 0.58 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0.47 Pain Relevance 0.12
Of these 10 genes, two (Tnfaip8 and Seh1l) significantly affect the production of IL-1?
Gene_expression (two) of Tnfaip8
9) Confidence 0.58 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0.33 Pain Relevance 0
Interestingly, RAW264.7 cells in which TNFAIP8 had been knocked down produced significantly more GM-CSF and significantly less IL-1?
Gene_expression (knocked) of TNFAIP8
10) Confidence 0.58 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0.47 Pain Relevance 0.23
To evaluate whether our cytokine results from the RAW264.7 knockdown experiments mimicked what was encountered in vivo, we first demonstrated by real time PCR that expression levels of Tnfaip8 and Seh1l are significantly lower in whole blood from A/J mice than from C57BL/6J mice (Figure 4B).
Gene_expression (expression) of Tnfaip8 in blood associated with cytokine
11) Confidence 0.58 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0.07 Pain Relevance 0.22
Taken together, Tnfaip8 is a strong candidate gene governing susceptibility to S. aureus through IL-1?
Gene_expression (governing) of Tnfaip8
12) Confidence 0.58 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0.43 Pain Relevance 0.27
Using real-time PCR, 6 of these 10 genes (Chmp1b, Dtwd2, Isoc1, Lman1, Tnfaip8, and Seh1l) showed significantly different expression levels between S. aureus-infected A/J and C57BL/6J.
Gene_expression (expression) of Tnfaip8
13) Confidence 0.52 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2932726 Disease Relevance 0.47 Pain Relevance 0.08
Thus, it may be that SEH1L contributes to susceptibility of A/J to S. aureus by increasing, along with TNFAIP8, macrophage production of GM-CSF.
Gene_expression (production) of TNFAIP8 in macrophage
14) Confidence 0.52 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0.35 Pain Relevance 0.27
mRNA expression, respectively) and CSS18 mice (42±3% [Tnfaip8] and 78±5% [Seh1l] of C57BL/6J PM?
Gene_expression (expression) of Tnfaip8
15) Confidence 0.50 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2932726 Disease Relevance 0.06 Pain Relevance 0.18

General Comments

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