INT232848

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.30
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Krt18) microtubule organizing center (Krt18) cytoplasm (Krt18)
Krt18 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 12 79.60 Quite High
alcohol 12 43.00 Quite Low
fibrosis 32 5.00 Very Low Very Low Very Low
Paracetamol 16 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 56 100.00 Very High Very High Very High
Ovarian Cancer 41 99.74 Very High Very High Very High
Aging 8 96.28 Very High Very High Very High
Stress 72 94.96 High High
Cancer 73 93.56 High High
Solid Tumor 16 85.28 High High
Nash(non-alcoholic Steatohepatitis) 28 81.76 Quite High
Parkinson's Disease 4 80.72 Quite High
Pressure And Volume Under Development 24 76.88 Quite High
Hepatotoxicity 8 74.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to determine if our cell lines presented these EOC markers, we monitored protein expression of Krt7, Krt8 and Krt18 by western blot.
Negative_regulation (monitored) of Gene_expression (expression) of Krt18 associated with ovarian cancer
1) Confidence 0.36 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.79 Pain Relevance 0
Dysbalanced K8/K18 expression precedes MDB formation, likely increases keratin misfolding and predisposes to posttranslational modifications, which may interfere with keratin refolding and/or repair.
Negative_regulation (Dysbalanced) of Gene_expression (expression) of K18
2) Confidence 0.35 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.30 Pain Relevance 0
Dysbalanced K8/K18 expression precedes MDB formation, likely increases keratin misfolding and predisposes to posttranslational modifications, which may interfere with keratin refolding and/or repair.
Negative_regulation (precedes) of Gene_expression (expression) of K18
3) Confidence 0.35 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.30 Pain Relevance 0
Several pathogenic mechanisms were implicated in this process (Fig. 4; Dobson 2004):1.Enhanced oxidative stress2.Disproportional K8/K18 expression together with keratin modifications3.Chaperone dysfunction4.Elevated p62 levels5.Insufficient protein degradation
Negative_regulation (stress2.Disproportional) of Gene_expression (expression) of K18
4) Confidence 0.35 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.22 Pain Relevance 0.08
The elevated K8/K18 ratio is crucial for MDB formation as shown in K18-knockout and K8 overexpressing animals, who are predisposed to MDB formation already upon short exposure to DDC and even form MDBs spontaneously during aging (Magin et al. 1998; Nakamichi et al. 2005).
Negative_regulation (predisposed) of Gene_expression (overexpressing) of K18-knockout associated with targeted disruption and aging
5) Confidence 0.30 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.70 Pain Relevance 0

General Comments

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