INT232877

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.88
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ABR) plasma membrane (ABR)
ABR (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 15 80.76 Quite High
Bile 15 69.36 Quite High
fibrosis 40 5.00 Very Low Very Low Very Low
Paracetamol 20 5.00 Very Low Very Low Very Low
Inflammation 15 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 70 99.20 Very High Very High Very High
Stress 90 98.00 Very High Very High Very High
Aging 10 96.96 Very High Very High Very High
Recurrence 5 83.04 Quite High
Nash(non-alcoholic Steatohepatitis) 35 79.68 Quite High
Parkinson's Disease 5 78.64 Quite High
End Stage Liver Disease 5 74.40 Quite High
Hepatotoxicity 10 72.60 Quite High
Gallstones 20 70.80 Quite High
Metabolic Disorder 5 69.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MDBs contain highly cross-linked keratins and the ablation of tissue transglutaminase effectively inhibits DDC-induced MDB formation (Zatloukal et al. 1992; Strnad et al. 2007).
Negative_regulation (inhibits) of MDB Binding (formation) of
1) Confidence 0.06 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.14 Pain Relevance 0
Of note, supplementation of S-adenosylmethionine or mitochondrially targeted antioxidants effectively diminishes MDB formation, thereby pointing to a central role of oxidative stress in MDB generation
Negative_regulation (diminishes) of MDB Binding (formation) of associated with stress
2) Confidence 0.06 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.35 Pain Relevance 0
P38 kinase-induced keratin network reorganization might be a necessary prerequisite for MDB formation, since p38 kinase inhibition prevented MDB formation in vitro (Nan et al. 2006).
Negative_regulation (prevented) of MDB Spec (might) Binding (formation) of
3) Confidence 0.06 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.13 Pain Relevance 0
The elevated K8/K18 ratio is crucial for MDB formation as shown in K18-knockout and K8 overexpressing animals, who are predisposed to MDB formation already upon short exposure to DDC and even form MDBs spontaneously during aging (Magin et al. 1998; Nakamichi et al. 2005).
Negative_regulation (predisposed) of MDB Binding (formation) of associated with targeted disruption and aging
4) Confidence 0.06 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.68 Pain Relevance 0
MDB formation in mice is reversible, since MDBs disappear after recovery on standard diet for 1 month.
Negative_regulation (reversible) of MDB Binding (formation) of
5) Confidence 0.06 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.57 Pain Relevance 0.14

General Comments

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