INT232885

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.50
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ABR) plasma membrane (ABR)
ABR (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 9 72.96 Quite High
alcohol 9 36.36 Quite Low
fibrosis 24 5.00 Very Low Very Low Very Low
Paracetamol 12 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 54 97.60 Very High Very High Very High
Targeted Disruption 42 83.16 Quite High
Aging 6 54.68 Quite High
Porphyria 3 44.00 Quite Low
Recurrence 3 38.64 Quite Low
Nash(non-alcoholic Steatohepatitis) 21 30.00 Quite Low
End Stage Liver Disease 3 30.00 Quite Low
Parkinson's Disease 3 28.96 Quite Low
Gallstones 12 26.40 Quite Low
Metabolic Disorder 3 25.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P38 kinase-induced keratin network reorganization might be a necessary prerequisite for MDB formation, since p38 kinase inhibition prevented MDB formation in vitro (Nan et al. 2006).
Positive_regulation (prerequisite) of MDB Spec (might) Binding (formation) of
1) Confidence 0.07 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.14 Pain Relevance 0
The MDB-inducing conditions both in humans and mice cause elevated levels of oxidative stress (Tephly et al. 1981; Mehta et al. 2002; Dey and Cederbaum 2006; Farrell and Larter 2006) and MDBs themselves were shown to contain misfolded keratins with increased ?
Positive_regulation (inducing) of MDB Binding (conditions) of associated with stress
2) Confidence 0.07 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.24 Pain Relevance 0.07
Alternatively, K8 hyperphosphorylation may induce MDB formation through inhibition of K8 degradation, which results in increased K8/K18 ratio (Ku and Omary 2000).
Spec (may) Positive_regulation (induce) of MDB Binding (formation) of
3) Confidence 0.07 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.13 Pain Relevance 0

General Comments

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