INT232886

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.42
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ABR) plasma membrane (ABR)
Anatomy Link Frequency
epithelium 2
ABR (Homo sapiens)
Pain Link Frequency Relevance Heat
GABAergic 46 100.00 Very High Very High Very High
gABA 59 91.04 High High
Glutamate 5 90.72 High High
GABA receptor 1 48.40 Quite Low
fibrosis 16 5.00 Very Low Very Low Very Low
Nicotine 9 5.00 Very Low Very Low Very Low
Paracetamol 8 5.00 Very Low Very Low Very Low
alcohol 7 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 38 99.74 Very High Very High Very High
Nicotine Addiction 68 98.66 Very High Very High Very High
Parkinson's Disease 2 98.20 Very High Very High Very High
Hepatotoxicity 4 97.76 Very High Very High Very High
Asthma 4 97.28 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 14 96.32 Very High Very High Very High
Targeted Disruption 28 55.52 Quite High
Aging 4 43.36 Quite Low
Porphyria 2 29.32 Quite Low
Apoptosis 46 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, mitochondrial oxidative stress seems to be involved in MDB formation in mice which is in good concordance to the mitochondrial dysfunction seen both in ASH and NASH patients (Pessayre 2007; Mantena et al. 2008; Zatloukal et al., unpublished data).
Regulation (involved) of Gene_expression (formation) of MDB associated with parkinson's disease, stress and nash(non-alcoholic steatohepatitis)
1) Confidence 0.06 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.77 Pain Relevance 0
On the other hand, autophagy is upregulated during MDB formation in mice and additional stimulation of autophagy attenuates MDB formation in certain conditions.
Regulation (upregulated) of Gene_expression (formation) of MDB
2) Confidence 0.06 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.31 Pain Relevance 0
Based on studies suggesting a role of the airway epithelial GABAergic system in asthma-related mucus overproduction, we hypothesized that cigarette smoking, another disorder associated with increased mucus production, may modulate GABAergic system-related gene expression levels in the airway epithelium.


Regulation (modulate) of Gene_expression (expression) of system-related gene in epithelium associated with asthma, nicotine addiction and gabaergic
3) Confidence 0.00 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2988726 Disease Relevance 0.34 Pain Relevance 0.45

General Comments

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