INT23290

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Context Info
Confidence 0.05
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.40
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
intestinal cells 1
adipocyte 1
Slc12a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 8 100.00 Very High Very High Very High
tetrodotoxin 7 99.84 Very High Very High Very High
Nicotine 2 99.78 Very High Very High Very High
repetitive firing 1 98.48 Very High Very High Very High
antagonist 4 97.76 Very High Very High Very High
Catecholamine 4 83.36 Quite High
tolerance 6 80.12 Quite High
local anesthetic 5 78.56 Quite High
Action potential 3 75.00 Quite High
agonist 1 46.16 Quite Low
Disease Link Frequency Relevance Heat
Obesity 100 99.90 Very High Very High Very High
Hypertrophy 8 88.64 High High
Diabetes Mellitus 8 84.16 Quite High
Impaired Glucose Tolerance 6 80.12 Quite High
Body Weight 12 65.48 Quite High
Hyperlipidemia 4 65.44 Quite High
Disorder Of Lipid Metabolism 12 63.60 Quite High
Insulin Resistance 4 35.44 Quite Low
Hyperplasia 4 32.56 Quite Low
Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results show that KCL may inhibit dietary fat absorption, thus, an effect of KCL on pancreatic lipase activity is to be investigative, because pancreatic lipase is a key enzyme that promotes the hydrolysis of triglycerides from dietary fat into fatty acids and 2-monoglycerol which are then absorbed into intestinal cells [26].
Negative_regulation (effect) of KCL in intestinal cells
1) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC3002919 Disease Relevance 0.71 Pain Relevance 0.04
The number of small adipocytes was increased and the number of large adipocytes was decreased in the subcutaneous (Figure 1), perirenal (Figure 2), and mesenteric (Figure 3) adipocyte tissues in the KCL group compared with in the control and acetic acid groups.
Negative_regulation (decreased) of KCL in adipocyte associated with obesity
2) Confidence 0.04 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC3002919 Disease Relevance 0.69 Pain Relevance 0
A significant correlation between inhibitions of both responses to KCl by the three Ca antagonists was observed, although the y-intercept and slope of the regression line for verapamil obtained by plotting the inhibition of the KCl-evoked contraction as a function of the inhibition of the evoked tritium overflow were greater than those for the other two antagonists.
Negative_regulation (inhibition) of KCl associated with antagonist
3) Confidence 0.03 Published 1985 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2409313 Disease Relevance 0 Pain Relevance 0.25
In contrast to KCl, glutamate release and the increase in [Ca2+]c with 4-aminopyridine were almost entirely blocked by tetrodotoxin, a result indicating repetitive firing of Na+ channels.
Negative_regulation (blocked) of KCl associated with tetrodotoxin, glutamate and repetitive firing
4) Confidence 0.03 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2553862 Disease Relevance 0 Pain Relevance 0.64
A coapplication of LA and K+ channel blocker resulted in larger inhibition of both KCl- and carbachol-evoked [Ca2+](i) transients than by LA alone.
Negative_regulation (inhibition) of KCl
5) Confidence 0.00 Published 2003 Journal Anesthesiology Section Body Doc Link 12717135 Disease Relevance 0 Pain Relevance 0
On the other hand, the sustained rise in [Ca]in was evoked by 0.1 mM ACh, 20 microM nicotine, or 30 mM KCl, which was suppressed by removal of extracellular Ca2+, but was little affected by TTX.
Negative_regulation (suppressed) of KCl associated with tetrodotoxin and nicotine
6) Confidence 0.00 Published 1989 Journal Jpn. J. Physiol. Section Abstract Doc Link 2482378 Disease Relevance 0 Pain Relevance 0.54

General Comments

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