INT232942

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.19
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT10) cytoplasm (KRT10)
Anatomy Link Frequency
keratinocyte 1
upper 1
KRT10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 12 6.20 Low Low
medulla 14 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 43 100.00 Very High Very High Very High
Dengue 78 82.32 Quite High
Epidermolytic Hyperkeratosis 6 80.32 Quite High
Skin Cancer 58 78.56 Quite High
Targeted Disruption 38 72.68 Quite High
Blister 4 71.20 Quite High
Cancer 170 55.92 Quite High
Viremia 7 48.40 Quite Low
Breast Cancer 22 39.72 Quite Low
Adenocarcinoma 92 37.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Surprisingly, although the differentiated parts of the hair follicle, such as suprabasal outer root sheath, upper companion layer, upper inner root sheath or the hair fiber, are heavily keratinized structures, all of them are free of K1/K10.
Negative_regulation (free) of K10 in upper
1) Confidence 0.21 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.52 Pain Relevance 0
In addition, however, there seem to exist further functional roles, as experimental data have demonstrated that K10 specifically inhibits proliferation and cell cycle progression of keratinocytes (Paramio et al. 1999; Koch and Roop 2004) and loss of K10 leads to increased keratinocyte turnover (Reichelt et al. 2004; for review, see Magin et al. 2007).
Negative_regulation (loss) of K10 in keratinocyte
2) Confidence 0.18 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.23 Pain Relevance 0
Previous studies have documented hyperendemicity of all four DENV serotypes with an approximate 5% annual risk of acquiring an infection in KPP [19].
Negative_regulation (infection) of KPP associated with infection
3) Confidence 0.07 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2577695 Disease Relevance 0.45 Pain Relevance 0

General Comments

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