INT232943

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.88
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT12)
KRT12 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 2 32.80 Quite Low
Inflammation 9 5.00 Very Low Very Low Very Low
medulla 7 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 19 87.68 High High
Cyst 11 84.24 Quite High
Acantholysis 1 83.36 Quite High
Disease 45 73.64 Quite High
Keloid Scars 4 63.72 Quite High
Alzheimer's Dementia 7 61.00 Quite High
Injury 13 52.16 Quite High
Ichthyosis 3 51.28 Quite High
Disorders Of The Lacrimal System 3 46.44 Quite Low
Cancer 87 46.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antibodies against these corneal keratins described include MAb AE5 (PROGEN, Heidelberg, Germany) which reacts with K3 and additionally with the related K76 (formerly K2p; see below; Collin et al. 1992b) and MAb AK12 which recognizes K12 (Chaloin-Dufau et al. 1993).


K12 Binding (recognizes) of
1) Confidence 0.47 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.19 Pain Relevance 0
Since a majority of MCD patients have mutations in KRT12, we hypothesized that a mutation in KRT12 might be associated with the phenotype observed in this family.
KRT12 Spec (might) Binding (associated) of
2) Confidence 0.37 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774455 Disease Relevance 0.46 Pain Relevance 0
As expected because of the mode of inheritance it is not linked to the KRT3 and KRT12 genes.
KRT12 Binding (linked) of
3) Confidence 0.20 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.23 Pain Relevance 0

General Comments

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