INT232944

Context Info Confidence 0.43 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.59 Pain Relevance 0.18

structural molecule activity (KRT75) intracellular (KRT75)

Anatomy Link Frequency hair follicle 1 beard 1 KRT75 (Homo sapiens)

Pain Link Frequency Relevance Heat medulla 14 98.20 Inflammation 12 71.12 Bile 2 5.00 Chronic pancreatitis 2 5.00 Potency 2 5.00

Disease Link Frequency Relevance Heat Skin Cancer 58 92.28 Cancer 170 88.48 Basal Cell Carcinoma 6 79.68 Loose Anagen Hair Syndrome 2 75.24 INFLAMMATION 10 71.12 Skin Appendage Disease 6 68.52 Adenoid Cystic Carcinoma 4 38.24 Poroma 2 36.72 Syringoma 4 36.00 Adenocarcinoma 92 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The hair follicle-specific epithelial keratin K75 (a) is specifically found in the hair companion layer (cl) and in the medulla (med) of sexual (e.g. beard) hairs.

Transcription (found) of K75 in beard associated with medulla

1) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.48 Pain Relevance 0.11

As the expression of this keratin as monitored by its mRNA synthesis using in situ hybridization starts from the bulbar matricial compartment of the hair follicle and the protein is still existent in the upper differentiated part where the K75 mRNA is no longer synthesized, it was one first but doubtless indication that this structure is an own individual compartment of the hair follicle and not the “innermost layer of the outer root sheath” (see Winter et al. 1998; Langbein and Schweizer 2005).

Neg (no) Transcription (synthesized) of K75 in hair follicle

2) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.11 Pain Relevance 0.06

General Comments

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