INT232944

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.59
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT75) intracellular (KRT75)
Anatomy Link Frequency
hair follicle 1
beard 1
KRT75 (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 14 98.20 Very High Very High Very High
Inflammation 12 71.12 Quite High
Bile 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 58 92.28 High High
Cancer 170 88.48 High High
Basal Cell Carcinoma 6 79.68 Quite High
Loose Anagen Hair Syndrome 2 75.24 Quite High
INFLAMMATION 10 71.12 Quite High
Skin Appendage Disease 6 68.52 Quite High
Adenoid Cystic Carcinoma 4 38.24 Quite Low
Poroma 2 36.72 Quite Low
Syringoma 4 36.00 Quite Low
Adenocarcinoma 92 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hair follicle-specific epithelial keratin K75 (a) is specifically found in the hair companion layer (cl) and in the medulla (med) of sexual (e.g. beard) hairs.
Transcription (found) of K75 in beard associated with medulla
1) Confidence 0.43 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.48 Pain Relevance 0.11
As the expression of this keratin as monitored by its mRNA synthesis using in situ hybridization starts from the bulbar matricial compartment of the hair follicle and the protein is still existent in the upper differentiated part where the K75 mRNA is no longer synthesized, it was one first but doubtless indication that this structure is an own individual compartment of the hair follicle and not the “innermost layer of the outer root sheath” (see Winter et al. 1998; Langbein and Schweizer 2005).
Neg (no) Transcription (synthesized) of K75 in hair follicle
2) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.11 Pain Relevance 0.06

General Comments

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