INT232945

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.54
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT18) cell cycle (KRT18) microtubule organizing center (KRT18)
cytoplasm (KRT18)
Anatomy Link Frequency
epithelial cells 2
KRT18 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 95.04 Very High Very High Very High
aspirin 44 92.80 High High
agonist 1 48.80 Quite Low
medulla 7 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cleidocranial Dysplasia 100 99.64 Very High Very High Very High
Adamantinoma 80 99.32 Very High Very High Very High
Sarcoma 1 98.02 Very High Very High Very High
Chordoma 1 97.56 Very High Very High Very High
Synovial Sarcoma 1 97.36 Very High Very High Very High
Generaliased Trisomy 1 97.04 Very High Very High Very High
Injury 13 96.24 Very High Very High Very High
INFLAMMATION 14 95.04 Very High Very High Very High
Frailty 1 93.76 High High
Cancer 93 87.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to a study on the antibodies against a subtype of cytokeratin by Hazelbag et al, cytokeratin (CK) in AD is different from synovial sarcoma, chordoma, or epithelial sarcoma.13 Benassi et al. insisted on a correlation between OFD and AD based on their results that showed positive CK19 and negative CK8 and CK18 staining in both OFD and AD cases.12 In a cytogenetic study, both OFD and AD have trisomies on chromosomes 7, 8, and 12.4,16
Positive_regulation (positive) of Neg (negative) Gene_expression (staining) of CK18 associated with sarcoma, adamantinoma, cleidocranial dysplasia, synovial sarcoma, generaliased trisomy and chordoma
1) Confidence 0.49 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628088 Disease Relevance 3.10 Pain Relevance 0
While highly specialized parenchymatous epithelial cells in their normal state, such as proximal tubular cells of the kidney, only express K8 and K18, this may change in reactive conditions.
Spec (may) Positive_regulation (change) of Gene_expression (express) of K18 in epithelial cells
2) Confidence 0.35 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.45 Pain Relevance 0.05
ELISA for specific IgG antibodies to CK8, CK18, and CK19
Positive_regulation (ELISA) of Gene_expression (antibodies) of CK18
3) Confidence 0.03 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 0 Pain Relevance 0.19

General Comments

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