INT232964

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 15
Disease Relevance 3.88
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT28) cytoplasm (KRT28)
Anatomy Link Frequency
hair follicle 1
lateral 1
IRS 1
keratinocytes 1
KRT28 (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 21 74.44 Quite High
Inflammation 18 13.88 Low Low
Pain 24 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Visceral Leishmaniasis 1128 99.72 Very High Very High Very High
Infection 84 99.38 Very High Very High Very High
Communicable Diseases 12 85.92 High High
Contagious Ecthyma 12 78.36 Quite High
Mycobacterial Infection 36 78.00 Quite High
Malaria 36 77.68 Quite High
Disease 255 61.08 Quite High
Skin Cancer 87 35.04 Quite Low
Bites And Stings 36 32.72 Quite Low
Cancer 255 31.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recombinant K28 protein (rK28) was produced by growing the transformed host cell HMS-174(DE3) in 2XYS with kanamycin using a fed-batch fermentation system.
Gene_expression (produced) of Recombinant K28
1) Confidence 0.48 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.13 Pain Relevance 0
Recombinant K28 protein (rK28) was produced by growing the transformed host cell HMS-174(DE3) in 2XYS with kanamycin using a fed-batch fermentation system.
Gene_expression (produced) of rK28
2) Confidence 0.48 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.13 Pain Relevance 0
K74 is restricted to the Huxley layer, whereas K73, K72 (Fig. 6c, h, i) and K28 are sequentially expressed in the IRS cuticle (Langbein et al. 2002, 2003, 2006; Langbein and Schweizer 2005; Fig. 6h, i).
Gene_expression (expressed) of K28 in IRS
3) Confidence 0.47 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0.07
The keratinocytes of all three compartments synthesize the IRS keratins K71 (Fig. 6b, h, i), K25, K27 and K28.
Gene_expression (synthesize) of K28 in keratinocytes
4) Confidence 0.47 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0.07
The K28 gene was synthesized at Blue Heron Biotechnology, Bothell, WA using the Genemaker technology with a six-histidine tag downstream of the N-terminal methionine.
Gene_expression (synthesized) of K28 gene
5) Confidence 0.43 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.41 Pain Relevance 0
Design of the k28 synthetic gene and expression of recombinant K28 protein
Gene_expression (expression) of k28
6) Confidence 0.43 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.06 Pain Relevance 0
Sudanese parasitology confirmed VL-positive and -negative sera (NHS, EC, NEC and other infection sera) were tested by ELISA on rK28, rK39, rK26, and rK9 to evaluate immunoreactivities (expressed as A450nm in Fig. 2) against individual proteins.
Gene_expression (expressed) of rK28 associated with visceral leishmaniasis and infection
7) Confidence 0.42 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.29 Pain Relevance 0
Evaluation of rK28 RDT in Sudan and Bangladesh
Gene_expression (Evaluation) of rK28
8) Confidence 0.42 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.30 Pain Relevance 0
Development of rK28-DPP RDT and prototype testing in Sudan
Gene_expression (-) of rK28
9) Confidence 0.42 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.73 Pain Relevance 0
Evaluation of two prototype lateral flow-based rK28 rapid tests on 53 VL patients in Sudan and 73 VL patients in Bangladesh provided promisingly high sensitivities (95.9% [95% CI?
Gene_expression (tests) of rK28 in lateral associated with visceral leishmaniasis
10) Confidence 0.42 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2939046 Disease Relevance 0.80 Pain Relevance 0
ELISA test results with Sudanese sera on rK28, rK39, rK26, and rK9
Gene_expression (rK9) of rK28
11) Confidence 0.42 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.20 Pain Relevance 0
All healthy U.S donors (30 samples) were test-negative on rK39, rK28 and rK26 ELISA. rK9 was least specific, as 4/30 U.S donors reacted non-specifically on the ELISA (data not shown).
Neg (negative) Gene_expression (negative) of rK28
12) Confidence 0.42 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.24 Pain Relevance 0
To evaluate accuracy of the rK28 RDT prototypes in detecting VL patients, independent studies were conducted with larger sera samples in Sudan and Bangladesh, two countries where VL is endemic.
Gene_expression (prototypes) of rK28 associated with visceral leishmaniasis
13) Confidence 0.42 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.53 Pain Relevance 0
Design of the k28 synthetic gene and expression of recombinant K28 protein
Gene_expression (expression) of recombinant K28
14) Confidence 0.37 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939046 Disease Relevance 0.06 Pain Relevance 0
Surprisingly, there were much more epithelial keratins with hair follicle specificity, namely the type II keratins K6irs1, K6irs2, K6irs3 and K6irs4 (now K71–K74) and type I keratins K25irs1, K25irs2, K25irs3 and K25irs4 (now K25–K28), all of them specifically expressed in and closely restricted to the various compartments of the hair follicle inner root sheath (Langbein et al. 2002, 2003, 2006; for review see Langbein and Schweizer 2005).
Gene_expression (expressed) of K28 in hair follicle
15) Confidence 0.32 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0

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