INT232965

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.66
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT10) cytoplasm (KRT10)
Anatomy Link Frequency
skin 1
internal 1
KRT10 (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 14 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Epidermolytic Hyperkeratosis 6 98.80 Very High Very High Very High
Cancer 253 97.92 Very High Very High Very High
Targeted Disruption 39 94.56 High High
Blister 4 94.24 High High
Cleidocranial Dysplasia 10 67.88 Quite High
Squamous Cell Carcinoma 4 50.00 Quite Low
Skin Cancer 58 40.24 Quite Low
Disease Progression 5 36.08 Quite Low
Breast Cancer 25 33.56 Quite Low
Carcinoma 47 29.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altogether, our results with K10 and Ki-67 shows that CTIP2 expression is linked to tumor differentiation state and proliferation.
K10 Binding (results) of associated with cancer
1) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.75 Pain Relevance 0
Despite their association with terminal epidermal differentiation and keratinization, K1 and K10 may be focally expressed in suprabasal cells of internal noncornifying stratified squamous epithelia (for references, see Moll 1998).
K10 Binding (association) of in internal
2) Confidence 0.18 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.51 Pain Relevance 0
The importance for epidermal integrity is underscored by the fact that point mutations in K1 and K10 are associated with the blistering disorder epidermolytic hyperkeratosis/bullous congenital ichthyosiform erythroderma (BCIE), initially presenting with skin blisters but later with thickened ichthyotic skin (for reviews, see Lane and McLean 2004; Omary et al. 2004).
K10 Binding (associated) of in skin associated with blister and epidermolytic hyperkeratosis
3) Confidence 0.18 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.40 Pain Relevance 0

General Comments

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