INT232982

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.65
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (KRT8) structural molecule activity (KRT8) nucleus (KRT8)
cytoskeleton organization (KRT8) cytoplasm (KRT8)
Anatomy Link Frequency
lung 1
KRT8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 30 92.20 High High
chemokine 3 89.72 High High
aspirin 132 80.40 Quite High
Paracetamol 3 71.24 Quite High
Chronic pancreatitis 1 36.12 Quite Low
Bile 1 8.88 Low Low
cINOD 12 5.00 Very Low Very Low Very Low
medulla 7 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 85 98.76 Very High Very High Very High
Asthma 180 94.76 High High
INFLAMMATION 32 92.20 High High
Breast Cancer 11 90.76 High High
Skin Cancer 29 86.48 High High
Apoptosis 32 84.92 Quite High
Carcinoma 22 77.44 Quite High
Lung Cancer 6 75.24 Quite High
Neuroendocrine Cancer 4 60.72 Quite High
Chronic Sinusitis 6 60.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another clinical application of K8/K18 is the monitoring of fragments of these keratins in the serum as serological tumor markers to monitor cancer load, cancer progression, and response to therapy.
Localization (application) of K8 associated with cancer
1) Confidence 0.44 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 1.33 Pain Relevance 0
IgG immunoblotting for CK8, CK18, and CK19
Localization (immunoblotting) of CK8
2) Confidence 0.30 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 0.42 Pain Relevance 0.04
IgG immunoblotting for CK8, CK18, and CK19
Localization (immunoblotting) of CK8
3) Confidence 0.30 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 0 Pain Relevance 0
Thus, CK8, CK18, and CK19, which were used in this study, have been found only in simple epithelia, including both bronchial and lung alveolar epithelial cells (17), which are the major target tissues of asthma.
Localization (found) of CK8 in lung associated with asthma
4) Confidence 0.30 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2729943 Disease Relevance 0.89 Pain Relevance 0.19

General Comments

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