INT232987

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.20
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT85)
Anatomy Link Frequency
nail 1
hair cuticle 1
KRT85 (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 14 93.72 High High
Inflammation 12 61.60 Quite High
Bile 2 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ectodermal Dysplasia 2 99.84 Very High Very High Very High
Rare Diseases 2 98.64 Very High Very High Very High
Skin Appendage Disease 6 97.16 Very High Very High Very High
Disease 26 95.52 Very High Very High Very High
Monilethrix 6 95.00 High High
Skin Cancer 58 82.76 Quite High
Hair Disease 2 80.96 Quite High
Cancer 170 78.96 Quite High
Basal Cell Carcinoma 6 70.16 Quite High
Loose Anagen Hair Syndrome 2 65.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hair keratin K85 (d) expression is found from the hair matrix to the upper cortex and the hair cuticle (cu), whereas K82 (e) is restricted to the hair cuticle.
Gene_expression (expression) of keratin K85 in hair cuticle
1) Confidence 0.10 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.42 Pain Relevance 0.11
A further, rare disease recently found to be related to a distinct mutation in the type II hair keratin K85 is ectodermal dysplasia of hair and nail type, characterized by total alopecia and severe nail dystrophy (Naeem et al. 2006).
Gene_expression (hair) of keratin K85 in nail associated with rare diseases, skin appendage disease and ectodermal dysplasia
2) Confidence 0.09 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.78 Pain Relevance 0

General Comments

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