INT232989

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.45
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT71)
Anatomy Link Frequency
hair follicle 1
keratinocytes 1
cuticle 1
KRT71 (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 21 98.52 Very High Very High Very High
Inflammation 18 66.40 Quite High
Bile 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 87 87.56 High High
Cancer 255 83.76 Quite High
Basal Cell Carcinoma 9 74.96 Quite High
Loose Anagen Hair Syndrome 3 70.52 Quite High
INFLAMMATION 15 66.40 Quite High
Skin Appendage Disease 9 63.80 Quite High
Adenocarcinoma 138 5.00 Very Low Very Low Very Low
Carcinoma 66 5.00 Very Low Very Low Very Low
Targeted Disruption 57 5.00 Very Low Very Low Very Low
Metastasis 48 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
K71 (b) is expressed in all compartments and K72 (c) in the cuticle (icu) of the hair inner root sheath (IRS).
Gene_expression (expressed) of K71 in cuticle
1) Confidence 0.46 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.45 Pain Relevance 0.11
The keratinocytes of all three compartments synthesize the IRS keratins K71 (Fig. 6b, h, i), K25, K27 and K28.
Gene_expression (synthesize) of IRS keratins K71 in keratinocytes
2) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0.06
Surprisingly, there were much more epithelial keratins with hair follicle specificity, namely the type II keratins K6irs1, K6irs2, K6irs3 and K6irs4 (now K71–K74) and type I keratins K25irs1, K25irs2, K25irs3 and K25irs4 (now K25–K28), all of them specifically expressed in and closely restricted to the various compartments of the hair follicle inner root sheath (Langbein et al. 2002, 2003, 2006; for review see Langbein and Schweizer 2005).
Gene_expression (expressed) of K71 in hair follicle
3) Confidence 0.35 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0 Pain Relevance 0

General Comments

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