INT232994

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 12
Disease Relevance 8.20
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (KRT10) cytoplasm (KRT10)
Anatomy Link Frequency
keratinocyte 2
horn 1
internal 1
skin 1
basal layer 1
KRT10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 30 56.52 Quite High
medulla 35 10.44 Low Low
alcohol 14 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
Chronic pancreatitis 5 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 145 99.86 Very High Very High Very High
Cancer 1006 99.32 Very High Very High Very High
Cleidocranial Dysplasia 52 98.38 Very High Very High Very High
Epidermolytic Hyperkeratosis 15 94.60 High High
Targeted Disruption 102 91.40 High High
Breast Cancer 76 90.04 High High
Adenocarcinoma 237 88.00 High High
Recurrence 12 79.12 Quite High
Disease Progression 26 79.04 Quite High
Metaplasia 20 76.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Less differentiated tumor (poorly differentiated tumors) express high CTIP2 levels with proliferative nature (colabel with Ki-67) and express very low levels of cytokeratin K10.


Gene_expression (express) of cytokeratin K10 associated with cancer
1) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.65 Pain Relevance 0
In squamous cell carcinomas focal expression of K1 and K10, usually in relation to maturation and keratinization, can be observed regardless of whether they are derived from the skin or from internal organs (for references, see Moll 1998).
Gene_expression (expression) of K10 in skin associated with skin cancer
2) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.51 Pain Relevance 0
Despite their association with terminal epidermal differentiation and keratinization, K1 and K10 may be focally expressed in suprabasal cells of internal noncornifying stratified squamous epithelia (for references, see Moll 1998).
Gene_expression (expressed) of K10 in internal
3) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.49 Pain Relevance 0
In well to moderately differentiated tumor samples with low level of CTIP2 expression, Cytokeratin 10 was expressed in clusters (Fig. 3A).
Gene_expression (expressed) of Cytokeratin 10 associated with cancer
4) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.68 Pain Relevance 0
In dysplasia samples, most of the supra basal layer cells which were positive for CTIP2 also expressed K10.
Gene_expression (expressed) of K10 in basal layer associated with cleidocranial dysplasia
5) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.70 Pain Relevance 0
Overall, K1 and K10 can be regarded as “keratinization markers” of keratinocytes.
Gene_expression (regarded) of K10 in keratinocytes
6) Confidence 0.33 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.53 Pain Relevance 0
K1/K10: major keratins of keratinocyte differentiation and keratinization
Gene_expression (/) of K10 in keratinocyte
7) Confidence 0.33 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.97 Pain Relevance 0.03
Some of the CTIP2 positive cells also expressed K10, and some CTIP2 positive cells were negative for K10.
Gene_expression (expressed) of K10
8) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.71 Pain Relevance 0
We observed cytoplasmic expression of K10 either in clusters or in scattered areas of the dysplasia samples and also in tumors with well or moderately differentiated status (Fig. 3A).
Gene_expression (expression) of K10 associated with cancer and cleidocranial dysplasia
9) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.70 Pain Relevance 0
In poorly differentiated tumors with less differentiation (less K10 positivity), high levels of CTIP2 was observed which did not express K10.
Neg (not) Gene_expression (express) of K10 associated with cancer
10) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.55 Pain Relevance 0
Some of the CTIP2 positive cells also expressed K10, and some CTIP2 positive cells were negative for K10.
Neg (negative) Gene_expression (negative) of K10
11) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671404 Disease Relevance 0.71 Pain Relevance 0
Focally, there may be expression of K1/K10 (particularly in higher differentiated tumor cells which can end in the formation of horn pearls), and—to a lesser extent—K4 and K13.
Gene_expression (expression) of K10 in horn associated with cancer
12) Confidence 0.30 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.97 Pain Relevance 0

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