INT232997

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.82
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (KRT6A)
Anatomy Link Frequency
keratinocytes 2
skin 1
KRT6A (Homo sapiens)
Pain Link Frequency Relevance Heat
medulla 21 48.80 Quite Low
Inflammation 18 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 36 100.00 Very High Very High Very High
Wound Healing 12 96.16 Very High Very High Very High
Targeted Disruption 57 82.56 Quite High
Skin Appendage Disease 9 36.16 Quite Low
Skin Cancer 87 35.36 Quite Low
Monilethrix 9 32.08 Quite Low
Apoptosis 33 30.56 Quite Low
Basal Cell Carcinoma 9 27.72 Quite Low
Pachyonychia Congenita 6 12.00 Low Low
Disease 39 11.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More recent experimental studies showed that after skin wounding, K6 and K16 are rapidly induced within 6 h in human keratinocytes at the wound edge, before migration and regeneration begins (Paladini et al. 1996).
Positive_regulation (induced) of K6 in keratinocytes associated with injury
1) Confidence 0.40 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.23 Pain Relevance 0
In early immunohistochemical studies using keratin group-specific MAbs, Weiss et al. (1984) demonstrated the induction of K6 (56-kd keratin) and K16 (48-kd keratin) in various hyperproliferative epidermal disorders, suggesting that these keratins may be molecular markers for hyperproliferative keratinocytes.
Positive_regulation (induction) of K6 in keratinocytes
2) Confidence 0.34 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.07 Pain Relevance 0
Another interesting feature of K17 is its inducibility after skin injury: after K6/K16 (see above), K17 is switched on in regenerating and migrating epidermal keratinocytes upon wound healing (Paladini et al. 1996).
Positive_regulation (inducibility) of K6 in skin associated with wound healing and injury
3) Confidence 0.12 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.52 Pain Relevance 0

General Comments

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