INT233

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Context Info
Confidence 0.42
First Reported 1977
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 31
Total Number 32
Disease Relevance 17.07
Pain Relevance 5.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast) extracellular region (Gast)
Anatomy Link Frequency
ECL cells 2
spinal 1
plasma 1
nerve trunk 1
head 1
Gast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 29 100.00 Very High Very High Very High
Enkephalin 7 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
bradykinin 1 100.00 Very High Very High Very High
Somatostatin 6 99.92 Very High Very High Very High
antagonist 32 99.82 Very High Very High Very High
Chronic pancreatitis 2 98.92 Very High Very High Very High
qutenza 1 98.60 Very High Very High Very High
imagery 7 95.08 Very High Very High Very High
Pain 9 92.96 High High
Disease Link Frequency Relevance Heat
Skin Infection 170 100.00 Very High Very High Very High
Infection 68 100.00 Very High Very High Very High
Ulcers 17 100.00 Very High Very High Very High
Hyperplasia 6 100.00 Very High Very High Very High
Duodenal Ulcer 9 99.68 Very High Very High Very High
Cancer 4 99.64 Very High Very High Very High
Streptococcus Infection 52 99.28 Very High Very High Very High
Rheumatic Fever 11 99.24 Very High Very High Very High
Syndrome 5 99.10 Very High Very High Very High
Pancreatitis 2 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Potentiation between histamine and either gastrin or acetylcholine may reflect postreceptor interaction between the distinct pathways and/or the ability of gastrin and acetylcholine to release histamine from mucosal ECL cells.
gastrin Binding (interaction) of in ECL cells
1) Confidence 0.42 Published 1993 Journal Baillieres Clin. Gastroenterol. Section Abstract Doc Link 8097411 Disease Relevance 0 Pain Relevance 0.09
Gas can also spontaneously enter and collect in the epidural space, but symptomatic epidural gas after spinal surgery is very rare.
Gas Binding (enter) of in spinal
2) Confidence 0.37 Published 2007 Journal Spine Section Body Doc Link 17471081 Disease Relevance 0 Pain Relevance 0
The clinical syndrome of primary G-cell hyperplasia appears to be associated with hyperplasia of G-cells rather than with the hypersecretion of gastrin by a normal number of G-cells.
gastrin Binding (associated) of associated with syndrome and hyperplasia
3) Confidence 0.37 Published 1984 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 6507721 Disease Relevance 0.71 Pain Relevance 0.08
[Effects of a coffee-antacid-mixture and a commercial coffee with regard to gastrin, pH and gastric secretion (author's transl)].
gastrin Binding (regard) of
4) Confidence 0.37 Published 1977 Journal Z Gastroenterol Section Title Doc Link 19888 Disease Relevance 0.83 Pain Relevance 0.06
A biologically active gastrin analogue, [125I](Nle11)-HG-13, appears to bind specifically to saturable binding sites on isolated rabbit gastric mucosal cells: Kd = 70 pM at pH 7.4 and at 37 degrees C.
gastrin Binding (bind) of
5) Confidence 0.35 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6290232 Disease Relevance 0 Pain Relevance 0.06
Gastrin binding was shown to be reversible and the dissociation rate was enhanced with cold gastrin.
Gastrin Binding (binding) of
6) Confidence 0.35 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6290232 Disease Relevance 0 Pain Relevance 0.12
Gastrin binding was not inhibited by secretin, glucagon, Met-enkephalin, physalaemin, eledoisin, BPP, VIP, carbachol, histamine, atropine or cimetidine.
Gastrin Binding (binding) of associated with enkephalin
7) Confidence 0.35 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6290232 Disease Relevance 0 Pain Relevance 0.14
None of these tumors showed endocrine immunoactivity for gastrin, somatostatin, insulin, glucagon, and enkephalin.
gastrin Binding (immunoactivity) of associated with cancer, somatostatin and enkephalin
8) Confidence 0.34 Published 1981 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 7240340 Disease Relevance 0.68 Pain Relevance 0.15
Gastrin accounted for less than 25% of the total immunoreactivity as measured with the nonspecific antiserum.
Gastrin Binding (accounted) of
9) Confidence 0.33 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2735417 Disease Relevance 0.31 Pain Relevance 0.40
Strong potentiation between histamine and either gastrin or acetylcholine reflects postreceptor interaction between the distinct pathways as well as the ability of acetylcholine and gastrin to release histamine from mucosal ECL cells.
gastrin Binding (interaction) of in ECL cells
10) Confidence 0.32 Published 1992 Journal Gastroenterol. Clin. North Am. Section Abstract Doc Link 1355465 Disease Relevance 0 Pain Relevance 0.18
This supports a role for IVIG in GAS NF, with or without STSS.
GAS NF Binding (role) of associated with streptococcus infection and skin infection
11) Confidence 0.27 Published 2004 Journal BMC Infect Dis Section Body Doc Link PMC544349 Disease Relevance 1.18 Pain Relevance 0.09
Clindamycin is recommended for GAS NF but whether clindamycin alone is as effective as penicillin plus clindamycin remains unclear.
GAS NF Binding (recommended) of associated with skin infection
12) Confidence 0.27 Published 2004 Journal BMC Infect Dis Section Body Doc Link PMC544349 Disease Relevance 1.39 Pain Relevance 0
High-affinity binding sites for gastrin on isolated rabbit gastric mucosal cells.
gastrin Binding (binding) of
13) Confidence 0.27 Published 1982 Journal Eur. J. Pharmacol. Section Title Doc Link 6290232 Disease Relevance 0 Pain Relevance 0.11
The specific virulence factors of the GAS which do cause NF and the basis of the inadequate host response in those patients who develop NF on infection with these GAS require further elucidation.


GAS Binding (infection) of associated with skin infection and infection
14) Confidence 0.24 Published 2004 Journal BMC Infect Dis Section Body Doc Link PMC544349 Disease Relevance 1.21 Pain Relevance 0
Recognition of the potential for secondary GAS infections and a high index of suspicion for the presence of necrotizing soft-tissue infection are essential in the evaluation of any child with fever and localized extremity pain with varicella.
GAS Binding (Recognition) of in extremity associated with pain, herpes zoster, fever and infection
15) Confidence 0.23 Published 1996 Journal J Pediatr Orthop Section Abstract Doc Link 8784712 Disease Relevance 2.29 Pain Relevance 0.21
L-365,260 binds potently and stereo-selectively to gastrin and CCK-B sites in guinea pig tissue.
gastrin Binding (binds) of
16) Confidence 0.23 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8510013 Disease Relevance 0 Pain Relevance 0.23
The plasma gastrin did not change significantly after secretin injection in the normal control or asymptomatic ulcer surgery patients, but rose in the duodenal ulcer patients and all the groups of patients with recurrent ulcer.
gastrin Binding (rose) of in plasma associated with duodenal ulcer and ulcers
17) Confidence 0.20 Published 1985 Journal Digestion Section Abstract Doc Link 4065447 Disease Relevance 1.17 Pain Relevance 0.07
Topical capsaicin applied to the vagal nerve trunk abolished the accumulation of sites binding both [125I]Bolton Hunter-labelled cholecystokinin-8 and heptadecapeptide gastrin indicating that both cholecystokininA and gastrin-cholecystokininB receptor populations were present on afferent fibres.
gastrin Binding (binding) of in nerve trunk associated with qutenza and cholecystokinin
18) Confidence 0.18 Published 1997 Journal Neuroscience Section Abstract Doc Link 9219953 Disease Relevance 0.05 Pain Relevance 0.30
The study underscores the association between T1/emm1 and outbreaks of serious GAS infections.
GAS Binding (association) of associated with infection
19) Confidence 0.18 Published 2009 Journal Scand. J. Infect. Dis. Section Abstract Doc Link 19922064 Disease Relevance 1.03 Pain Relevance 0.09
The antibodies were of an affinity high enough to compete with the cholecystokinin B/gastrin receptor for G17 binding with adequate capacity to neutralize postprandial gastrin surges.
gastrin Binding (compete) of associated with cholecystokinin
20) Confidence 0.11 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 11156225 Disease Relevance 0.91 Pain Relevance 0.13

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