INT2330

Context Info Confidence 0.10 First Reported 1976 Last Reported 2009 Negated 5 Speculated 12 Reported most in Abstract Documents 78 Total Number 90 Disease Relevance 20.46 Pain Relevance 32.60

Anatomy Link Frequency blood 74 brain 3 cerebrospinal fluid 1 platelet 1 crown 1 CB (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 134 100.00 isoflurane 97 100.00 cva 63 100.00 Morphine 42 100.00 halothane 36 100.00 Pain 20 100.00 Sumatriptan 19 100.00 Opioid 19 100.00 narcan 18 100.00 opiate 14 100.00

Disease Link Frequency Relevance Heat Cv General 3 Under Development 31 100.00 Pressure Volume 2 Under Development 19 100.00 Hypotension 9 100.00 Pressure And Volume Under Development 6 100.00 Hypoglycemia 6 100.00 Neutropenia 4 100.00 Hypothermia 4 99.96 Cv General 4 Under Development 32 99.92 Pain 16 99.84 Hypoxia 21 99.76

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Key:

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The first purpose of this paper was to review the eCB system in detail, highlighting aspects of interest to bodyworkers, especially eCB modulation of pain and inflammation.

Regulation (modulation) of eCB associated with pain and inflammation

1) Confidence 0.10 Published 2008 Journal J Bodyw Mov Ther Section Abstract Doc Link 19083670 Disease Relevance 0.38 Pain Relevance 0.45

The present study analyzed effects of dibutyryl cyclic AMP (DB-cAMP) and cytochalasin B (CB) on the morphology of cultured aortic smooth muscle cells (SMC) from rat using phase-contrast microscopy, scanning electron microscopy, and fluorescence staining of actin filaments by the NBD-phallacidin method.

Spec (analyzed) Regulation (effects) of CB in filaments

2) Confidence 0.07 Published 1989 Journal Cell Tissue Res. Section Abstract Doc Link 2538239 Disease Relevance 0 Pain Relevance 0.04

We re-examined this issue and compared the effects of the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe), phorbol myristate acetate (PMA), ATP, platelet activating factor (PAF), cytochalasin B (CB) and prostaglandin E1 (PGE1) with those of various opioids on O2- formation in human neutrophils and HL-60 leukemic cells under defined experimental conditions.

Regulation (effects) of CB in platelet associated with opioid

3) Confidence 0.02 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2552328 Disease Relevance 0 Pain Relevance 0.63

Neither changes in cerebral blood flow (CBF), as measured by the 33Xenon inhalation technique, nor peripheral side-effects were noted in the control group.

Neg (Neither) Regulation (changes) of cerebral blood flow in blood

4) Confidence 0.01 Published 1982 Journal Nouv Presse Med Section Abstract Doc Link 7043395 Disease Relevance 0.70 Pain Relevance 0.41

In an effort to study changes in cerebral blood flow (CBF), intracranial pressure (ICP) and intracranial compliance (ICC) simultaneously, we have developed a chronic model in rats using a pial window crown with two ports.

Regulation (changes) of cerebral blood flow in crown associated with cva

5) Confidence 0.01 Published 1997 Journal J. Neurosci. Methods Section Abstract Doc Link 9288647 Disease Relevance 0.33 Pain Relevance 0.24

Regional alterations in cerebral blood flow (CBF) are widely used as a surrogate for neuronal function based on an intact coupling between changes in regional CBF and metabolism, activation-flow coupling (AFC).

Regulation (alterations) of cerebral blood flow in neuronal

6) Confidence 0.01 Published 1998 Journal Brain Res. Section Abstract Doc Link 9689458 Disease Relevance 0 Pain Relevance 0.17

A rostral vasodilatory effect has also been described, but changes in cerebral blood flow (CBF) have been poorly delineated.

Regulation (changes) of cerebral blood flow in blood

7) Confidence 0.01 Published 2000 Journal J. Neurosurg. Section Abstract Doc Link 10879761 Disease Relevance 0.26 Pain Relevance 0.51

The present study was designed to examine the effect of sumatriptan on regional cerebral blood flow (CBF) during migraine headache.

Spec (examine) Regulation (effect) of cerebral blood flow in blood associated with sumatriptan, migraine and headache

8) Confidence 0.01 Published 2001 Journal No To Shinkei Section Abstract Doc Link 11517486 Disease Relevance 0.25 Pain Relevance 1.02

The effects of spinal anesthesia on cerebral blood flow in the very elderly.

Regulation (effects) of cerebral blood flow in blood associated with anesthesia

9) Confidence 0.01 Published 2009 Journal Anesth. Analg. Section Title Doc Link 19299802 Disease Relevance 0.29 Pain Relevance 0.28

Effects of sumatriptan on cerebral blood flow under normo- and hypercapnia in rats.

Regulation (Effects) of cerebral blood flow in blood associated with sumatriptan and hypercapnia

10) Confidence 0.01 Published 2002 Journal Cephalalgia Section Title Doc Link 12133047 Disease Relevance 0.35 Pain Relevance 0.58

In this study, we assessed the effects of spinal anesthesia on cerebral blood flow (CBF) in very elderly patients.

Regulation (effects) of cerebral blood flow in spinal associated with anesthesia

11) Confidence 0.01 Published 2009 Journal Anesth. Analg. Section Abstract Doc Link 19299802 Disease Relevance 0.28 Pain Relevance 0.27

After injection of 0.6 or 6.0 microg/kg sumatriptan succinate, no significant change in cerebral blood flow (CBF) was observed either in the striatum or in the parietal cortex.

Neg (no) Regulation (change) of cerebral blood flow in parietal cortex associated with sumatriptan

12) Confidence 0.01 Published 2002 Journal Cephalalgia Section Abstract Doc Link 12133047 Disease Relevance 0.33 Pain Relevance 0.57

The effect of tolbutamide on cerebral blood flow during hypoxia and hypercapnia in the anaesthetized rat.

Regulation (effect) of cerebral blood flow in blood associated with anesthesia, hypoxia and hypercapnia

13) Confidence 0.00 Published 1993 Journal Pflugers Arch. Section Title Doc Link 8309797 Disease Relevance 0.79 Pain Relevance 0.22

Cases and controls were excluded if they had history of Schizophrenia, Bipolar disorder, Major Depression, Eating Disorder, autoimmune disease, or malignancy, which could conceivably alter eCB concentrations.

Regulation (alter) of eCB associated with malignant neoplastic disease, autoimmune disease, manic depressive disorder, depression, eating disorder and schizophrenia

14) Confidence 0.00 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2631501 Disease Relevance 1.40 Pain Relevance 0.14

The effects of diazepam on cerebral blood flow (CBF) and cerebral oxygen uptake (CMRO2) was studied using a 133xenon modification of the Kety-Schmidt (1948) technique in paralyzed, artifically ventilated rats with and without simultaneous administration of 70 per cent nitrous oxide.

Regulation (effects) of cerebral blood flow in blood associated with paralysis

15) Confidence 0.00 Published 1976 Journal Anesthesiology Section Abstract Doc Link 962180 Disease Relevance 0.17 Pain Relevance 0.07

In this experiment we assessed changes in cerebral blood flow (CBF) after intracarotid infusion of nitroprusside and adenosine.

Regulation (changes) of cerebral blood flow in blood associated with adenocard

16) Confidence 0.00 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 11812706 Disease Relevance 0.16 Pain Relevance 0.29

Our methods for the control of intracranial pressure (ICP) and cerebral blood flow (CBF) during neurosurgical anesthesia were as follows: (1) avoidance of the drugs adversely influenced on ICP; (2) use of lidocaine iv. infusion; (3) prevention of hypercapnia; (4) maintenance of adequate perfusion of vital organs; (5) drainage of cerebrospinal fluid if necessary; (6) use of free radical clearing agents.

Regulation (control) of cerebral blood flow in cerebrospinal fluid associated with anesthesia, hypercapnia, cva and lidocaine

17) Confidence 0.00 Published 1991 Journal Zhonghua Wai Ke Za Zhi Section Abstract Doc Link 1874098 Disease Relevance 0.56 Pain Relevance 0.55

Effects of neutropenia on edema, histology, and cerebral blood flow after traumatic brain injury in rats.

Regulation (Effects) of cerebral blood flow in blood associated with neutropenia, pressure and volume under development and brain injury

18) Confidence 0.00 Published 1994 Journal J. Neurotrauma Section Title Doc Link 7996584 Disease Relevance 1.51 Pain Relevance 0.21

Methadone transiently increased cardiac output (CO) and mean arterial pressure, but did not alter cerebral blood flow (CBF) or cause significant respiratory depression.

Neg (not) Regulation (alter) of cerebral blood flow in respiratory associated with depression, respiratory failure and methadone

19) Confidence 0.00 Published 2005 Journal J Pharmacokinet Pharmacodyn Section Abstract Doc Link 16284915 Disease Relevance 0.10 Pain Relevance 0.70

The effect of decreased cerebral perfusion pressure (CPP) on regional cerebral blood flow (CBF) with radiolabeled microspheres in dogs receiving either 1.4% or 2.8% isoflurane following anesthesia induction with thiopental (12 mg/kg, iv bolus) was studied.

Regulation (effect) of cerebral blood flow in blood associated with anesthesia and isoflurane

20) Confidence 0.00 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3177910 Disease Relevance 0.12 Pain Relevance 0.33

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