INT233007

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.46
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (VIM) plasma membrane (VIM) cytoskeleton (VIM)
cytoplasm (VIM)
Anatomy Link Frequency
Section 3 1
epithelium 1
filaments 1
neural 1
VIM (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 16 100.00 Very High Very High Very High
Inflammation 10 99.18 Very High Very High Very High
Chronic pancreatitis 11 90.60 High High
Pain 7 67.20 Quite High
Paresthesia 1 65.92 Quite High
chemokine 3 59.52 Quite High
medulla 7 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 1 99.40 Very High Very High Very High
INFLAMMATION 9 99.18 Very High Very High Very High
Injury 13 98.76 Very High Very High Very High
Adhesions 40 98.08 Very High Very High Very High
Cancer 255 97.04 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 94.60 High High
Fibrosarcoma 5 91.44 High High
Pancreatitis 11 90.60 High High
Pancreatic Cancer 56 88.88 High High
Breast Cancer 34 85.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These filaments consist of a number of different members, including vimentin and the cytokeratin proteins.
Negative_regulation (number) of vimentin in filaments
1) Confidence 0.41 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 1.05 Pain Relevance 0.09
Vimentin was constantly positive with S-100 showing negativity, thus ruling out the possibility of neural tumours.
Negative_regulation (positive) of Vimentin in neural associated with cancer
2) Confidence 0.24 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC3020523 Disease Relevance 1.19 Pain Relevance 0.10
Upon various types of injury such as inflammation or atrophy these cells may additionally switch on K7 and K19, sometimes also K17 (as well as vimentin) and thus express four to five instead of two keratins (Moll et al. 1991).
Negative_regulation (switch) of vimentin associated with inflammation, frailty and injury
3) Confidence 0.11 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.45 Pain Relevance 0.05
These proteins included tissue inhibitor of metalloproteinase 1 (TIMP-1), vimentin, and pigment epithelium-derived growth factor (PEDF).
Negative_regulation (inhibitor) of vimentin in epithelium associated with metalloproteinase
4) Confidence 0.10 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846341 Disease Relevance 0.15 Pain Relevance 0.05
Western blot analysis detected a slight decrease in filamin-A and vimentin in WT samples, while the decrease in annexin A1 or A2 was less obvious (Fig. 5A).
Negative_regulation (decrease) of vimentin
5) Confidence 0.09 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.06 Pain Relevance 0
Genistein also decreased the levels of vimentin, a protein that is typically associated with a mesenchymal, or invasive, state (see Section 3.2).
Negative_regulation (decreased) of vimentin in Section 3
6) Confidence 0.07 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.58 Pain Relevance 0.07

General Comments

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